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STRINGSTRING
DPRX DPRX RARRES2 RARRES2 RAX2 RAX2 ANXA11 ANXA11 LYPD1 LYPD1 PLAC9 PLAC9 DYDC2 DYDC2 EGLN1 EGLN1 DYDC1 DYDC1 TMEM254 TMEM254 RDH10 RDH10
"PLAC9" - Placenta-specific protein 9 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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PLAC9Placenta-specific protein 9; Placenta specific 9; Belongs to the PLAC9 family (97 aa)    
Predicted Functional Partners:
ANXA11
Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the annexin family (505 aa)
      
   
  0.743
LYPD1
Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha- 4-beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4-beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety; LY6/PLAUR domain containing (141 aa)
            
  0.730
TMEM254
Transmembrane protein 254 (123 aa)
            
  0.670
EGLN1
Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is [...] (426 aa)
            
  0.606
RAX2
Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter; PRD class homeoboxes and pseudogenes (184 aa)
            
  0.595
RDH10
Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol; Short chain dehydrogenase/reductase superfamily (341 aa)
            
  0.526
DPRX
Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes (191 aa)
            
  0.515
DYDC1
DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis (177 aa)
            
  0.514
DYDC2
DPY30 domain containing 2; Belongs to the dpy-30 family (191 aa)
            
  0.511
RARRES2
Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...] (163 aa)
      
   
  0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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