| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DPY30 | DYDC1 | ENSP00000345837 | ENSP00000361278 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | 0.574 |
| DPY30 | DYDC2 | ENSP00000345837 | ENSP00000361272 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | DPY30 domain containing 2; Belongs to the dpy-30 family | 0.574 |
| DPY30 | NME5 | ENSP00000345837 | ENSP00000265191 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | 0.470 |
| DPY30 | SETD1B | ENSP00000345837 | ENSP00000442924 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro; Belongs t [...] | 0.997 |
| DPY30 | WDR5 | ENSP00000345837 | ENSP00000351446 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family | 0.990 |
| DYDC1 | DPY30 | ENSP00000361278 | ENSP00000345837 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | 0.574 |
| DYDC1 | DYDC2 | ENSP00000361278 | ENSP00000361272 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | DPY30 domain containing 2; Belongs to the dpy-30 family | 0.622 |
| DYDC1 | SETD1B | ENSP00000361278 | ENSP00000442924 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro; Belongs t [...] | 0.540 |
| DYDC1 | SH2D4B | ENSP00000361278 | ENSP00000345295 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | SH2 domain containing 4B | 0.717 |
| DYDC1 | TMEM254 | ENSP00000361278 | ENSP00000361355 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | Transmembrane protein 254 | 0.567 |
| DYDC1 | TMEM61 | ENSP00000361278 | ENSP00000360315 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | Transmembrane protein 61 | 0.559 |
| DYDC1 | TSPAN14 | ENSP00000361278 | ENSP00000396270 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10- mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity); Belongs to the tetraspanin (TM4SF) family | 0.626 |
| DYDC1 | WDR5 | ENSP00000361278 | ENSP00000351446 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family | 0.550 |
| DYDC2 | DPY30 | ENSP00000361272 | ENSP00000345837 | DPY30 domain containing 2; Belongs to the dpy-30 family | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | 0.574 |
| DYDC2 | DYDC1 | ENSP00000361272 | ENSP00000361278 | DPY30 domain containing 2; Belongs to the dpy-30 family | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis | 0.622 |
| DYDC2 | NME5 | ENSP00000361272 | ENSP00000265191 | DPY30 domain containing 2; Belongs to the dpy-30 family | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | 0.755 |
| DYDC2 | SETD1B | ENSP00000361272 | ENSP00000442924 | DPY30 domain containing 2; Belongs to the dpy-30 family | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro; Belongs t [...] | 0.540 |
| DYDC2 | SH2D4B | ENSP00000361272 | ENSP00000345295 | DPY30 domain containing 2; Belongs to the dpy-30 family | SH2 domain containing 4B | 0.722 |
| DYDC2 | SPTSSA | ENSP00000361272 | ENSP00000298130 | DPY30 domain containing 2; Belongs to the dpy-30 family | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA | 0.646 |
| DYDC2 | TMEM254 | ENSP00000361272 | ENSP00000361355 | DPY30 domain containing 2; Belongs to the dpy-30 family | Transmembrane protein 254 | 0.559 |
