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STRINGSTRING
TSPAN13 TSPAN13 PHB PHB AGR2 AGR2 EFCAB7 EFCAB7 TP73 TP73 TSPAN1 TSPAN1 SLC19A2 SLC19A2 CTCF CTCF TM4SF5 TM4SF5 TM4SF1 TM4SF1 CDHR1 CDHR1
"TSPAN1" - Tetraspanin-1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN1Tetraspanin-1; Tetraspanin 1; Tetraspanins (241 aa)    
Predicted Functional Partners:
TM4SF1
Transmembrane 4 L six family member 1 (202 aa)
      
   
  0.670
TM4SF5
Transmembrane 4 L six family member 5; Belongs to the L6 tetraspanin family (197 aa)
      
   
  0.640
PHB
Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (272 aa)
            
  0.632
TP73
Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein (636 aa)
            
  0.563
SLC19A2
Thiamine transporter 1; High-affinity transporter for the intake of thiamine; Solute carriers (497 aa)
            
  0.561
AGR2
Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion; Protein disulfide isomerases (175 aa)
      
   
  0.542
CDHR1
Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); Cadherin related (859 aa)
            
  0.539
CTCF
Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] (727 aa)
            
  0.525
EFCAB7
EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing (629 aa)
            
  0.498
TSPAN13
Tetraspanin-13; Tetraspanin 13; Tetraspanins (204 aa)
      
   
  0.496
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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