• Version:
  • 11.0 [archived version]
STRINGSTRING
AP1S3 AP1S3 ZNF81 ZNF81 ZNF804B ZNF804B LSM14B LSM14B EFCAB14 EFCAB14 ZNF862 ZNF862 EIF2S3L EIF2S3L ASCC1 ASCC1 MRPS10 MRPS10 TTC9C TTC9C C11orf73 C11orf73
"EFCAB14" - EF-hand calcium-binding domain-containing protein 14 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
EFCAB14EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 (495 aa)    
Predicted Functional Partners:
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] (472 aa)
           
  0.571
TTC9C
Tetratricopeptide repeat domain containing; Belongs to the TTC9 family (171 aa)
           
  0.557
ZNF804B
Zinc finger protein 804B (1349 aa)
           
  0.532
ZNF862
Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1169 aa)
           
  0.515
C11orf73
Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family (197 aa)
           
  0.474
LSM14B
Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins (385 aa)
           
  0.473
MRPS10
Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family (201 aa)
           
  0.447
AP1S3
AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (154 aa)
           
  0.441
ASCC1
Activating signal cointegrator 1 complex subunit 1; Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction (400 aa)
           
  0.441
ZNF81
Zinc finger protein 81; May be involved in transcriptional regulation; X-linked mental retardation (661 aa)
           
  0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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