node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP1S3 | EFCAB14 | ENSP00000379891 | ENSP00000361001 | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | 0.441 |
ASCC1 | EFCAB14 | ENSP00000339404 | ENSP00000361001 | Activating signal cointegrator 1 complex subunit 1; Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | 0.441 |
ASCC1 | ZNF862 | ENSP00000339404 | ENSP00000223210 | Activating signal cointegrator 1 complex subunit 1; Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction | Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.433 |
C11orf73 | EFCAB14 | ENSP00000278483 | ENSP00000361001 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | 0.474 |
C11orf73 | EIF2S3L | ENSP00000278483 | ENSP00000445077 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] | 0.514 |
C11orf73 | MRPS10 | ENSP00000278483 | ENSP00000053468 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family | 0.471 |
C11orf73 | TTC9C | ENSP00000278483 | ENSP00000325266 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.528 |
EFCAB14 | AP1S3 | ENSP00000361001 | ENSP00000379891 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking | 0.441 |
EFCAB14 | ASCC1 | ENSP00000361001 | ENSP00000339404 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Activating signal cointegrator 1 complex subunit 1; Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction | 0.441 |
EFCAB14 | C11orf73 | ENSP00000361001 | ENSP00000278483 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | 0.474 |
EFCAB14 | EIF2S3L | ENSP00000361001 | ENSP00000445077 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] | 0.571 |
EFCAB14 | LSM14B | ENSP00000361001 | ENSP00000279068 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins | 0.473 |
EFCAB14 | MRPS10 | ENSP00000361001 | ENSP00000053468 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family | 0.447 |
EFCAB14 | TTC9C | ENSP00000361001 | ENSP00000325266 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.557 |
EFCAB14 | ZNF804B | ENSP00000361001 | ENSP00000329638 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Zinc finger protein 804B | 0.532 |
EFCAB14 | ZNF81 | ENSP00000361001 | ENSP00000366153 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Zinc finger protein 81; May be involved in transcriptional regulation; X-linked mental retardation | 0.440 |
EFCAB14 | ZNF862 | ENSP00000361001 | ENSP00000223210 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.515 |
EIF2S3L | C11orf73 | ENSP00000445077 | ENSP00000278483 | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress- acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus; Belongs to the OPI10 family | 0.514 |
EIF2S3L | EFCAB14 | ENSP00000445077 | ENSP00000361001 | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 | 0.571 |
EIF2S3L | MRPS10 | ENSP00000445077 | ENSP00000053468 | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GD [...] | Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family | 0.713 |