ANKRD22 protein (human) - STRING database

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ANKRD22

Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing (191 aa)

Predicted Functional Partners:

STAMBPL1

0.692

IMPA2

0.683

LIPM

0.645

UGP2

0.636

ACPT

0.626

LIPF

0.536

LIPK

0.517

TMEM156

0.513

ASB4

0.506

BATF2

0.489

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPT	ANKRD22	ENSP00000270593	ENSP00000360998	Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	0.626
ACPT	IMPA2	ENSP00000270593	ENSP00000269159	Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis	Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain	0.626
ACPT	UGP2	ENSP00000270593	ENSP00000338703	Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis	UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family	0.614
ANKRD22	ACPT	ENSP00000360998	ENSP00000270593	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis	0.626
ANKRD22	ASB4	ENSP00000360998	ENSP00000321388	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Ankyrin repeat and SOCS box protein 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity); Belongs to the ankyrin SOCS box (ASB) family	0.506
ANKRD22	BATF2	ENSP00000360998	ENSP00000301887	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5’-TGA[CG]TCA-3’ and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced b [...]	0.489
ANKRD22	IMPA2	ENSP00000360998	ENSP00000269159	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain	0.683
ANKRD22	LIPF	ENSP00000360998	ENSP00000377900	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Lipase F, gastric type; Lipases	0.536
ANKRD22	LIPK	ENSP00000360998	ENSP00000383900	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lipases	0.517
ANKRD22	LIPM	ENSP00000360998	ENSP00000383901	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Lipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Belongs to the AB hydrolase superfamily. Lipase family	0.645
ANKRD22	STAMBPL1	ENSP00000360998	ENSP00000360994	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	AMSH-like protease; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains; Belongs to the peptidase M67C family	0.692
ANKRD22	TMEM156	ENSP00000360998	ENSP00000371364	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	Transmembrane protein 156	0.513
ANKRD22	UGP2	ENSP00000360998	ENSP00000338703	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family	0.636
ASB4	ANKRD22	ENSP00000321388	ENSP00000360998	Ankyrin repeat and SOCS box protein 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity); Belongs to the ankyrin SOCS box (ASB) family	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	0.506
BATF2	ANKRD22	ENSP00000301887	ENSP00000360998	Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5’-TGA[CG]TCA-3’ and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced b [...]	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	0.489
IMPA2	ACPT	ENSP00000269159	ENSP00000270593	Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain	Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis	0.626
IMPA2	ANKRD22	ENSP00000269159	ENSP00000360998	Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	0.683
IMPA2	UGP2	ENSP00000269159	ENSP00000338703	Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2’- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain	UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family	0.547
LIPF	ANKRD22	ENSP00000377900	ENSP00000360998	Lipase F, gastric type; Lipases	Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing	0.536
LIPF	STAMBPL1	ENSP00000377900	ENSP00000360994	Lipase F, gastric type; Lipases	AMSH-like protease; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains; Belongs to the peptidase M67C family	0.547

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