| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGFG1 | ARF6 | ENSP00000387282 | ENSP00000298316 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | 0.560 |
| AGFG1 | RABL6 | ENSP00000387282 | ENSP00000360727 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.628 |
| AK8 | CAMSAP1 | ENSP00000298545 | ENSP00000374183 | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity; Adenylate kinases | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] | 0.735 |
| AK8 | GTF3C5 | ENSP00000298545 | ENSP00000361180 | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity; Adenylate kinases | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | 0.592 |
| AK8 | RABL6 | ENSP00000298545 | ENSP00000360727 | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity; Adenylate kinases | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.574 |
| ARF6 | AGFG1 | ENSP00000298316 | ENSP00000387282 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | 0.560 |
| ARF6 | RABL6 | ENSP00000298316 | ENSP00000360727 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.560 |
| ARL15 | RABL6 | ENSP00000433427 | ENSP00000360727 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.560 |
| CAMSAP1 | AK8 | ENSP00000374183 | ENSP00000298545 | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity; Adenylate kinases | 0.735 |
| CAMSAP1 | GTF3C5 | ENSP00000374183 | ENSP00000361180 | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | 0.473 |
| CAMSAP1 | RABL6 | ENSP00000374183 | ENSP00000360727 | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.551 |
| CCDC183 | RABL6 | ENSP00000338013 | ENSP00000360727 | Coiled-coil domain containing 183 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.792 |
| DPP7 | GTF3C5 | ENSP00000360635 | ENSP00000361180 | Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; DASH family | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | 0.434 |
| DPP7 | RABL6 | ENSP00000360635 | ENSP00000360727 | Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; DASH family | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.688 |
| GTF3C5 | AK8 | ENSP00000361180 | ENSP00000298545 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity; Adenylate kinases | 0.592 |
| GTF3C5 | CAMSAP1 | ENSP00000361180 | ENSP00000374183 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] | 0.473 |
| GTF3C5 | DPP7 | ENSP00000361180 | ENSP00000360635 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; DASH family | 0.434 |
| GTF3C5 | RABL6 | ENSP00000361180 | ENSP00000360727 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters; General transcription factors | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.601 |
| KRI1 | RABL6 | ENSP00000320917 | ENSP00000360727 | KRI1 homolog; Belongs to the KRI1 family | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | 0.551 |
| RABL6 | AGFG1 | ENSP00000360727 | ENSP00000387282 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication; ArfGAPs | 0.628 |
