| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEPD1 | LONRF3 | ENSP00000242108 | ENSP00000360690 | Endonuclease/exonuclease/phosphatase family domain containing 1 | LON peptidase N-terminal domain and ring finger 3 | 0.590 |
| EEPD1 | MTMR8 | ENSP00000242108 | ENSP00000363985 | Endonuclease/exonuclease/phosphatase family domain containing 1 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | 0.567 |
| IL1RAPL1 | LONRF3 | ENSP00000368278 | ENSP00000360690 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | LON peptidase N-terminal domain and ring finger 3 | 0.553 |
| IL1RAPL1 | RNF149 | ENSP00000368278 | ENSP00000295317 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation; Ring finger proteins | 0.627 |
| IL1RAPL1 | TBC1D8 | ENSP00000368278 | ENSP00000366036 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s); GRAM domain containing | 0.627 |
| LONRF3 | EEPD1 | ENSP00000360690 | ENSP00000242108 | LON peptidase N-terminal domain and ring finger 3 | Endonuclease/exonuclease/phosphatase family domain containing 1 | 0.590 |
| LONRF3 | IL1RAPL1 | ENSP00000360690 | ENSP00000368278 | LON peptidase N-terminal domain and ring finger 3 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.553 |
| LONRF3 | MTMR8 | ENSP00000360690 | ENSP00000363985 | LON peptidase N-terminal domain and ring finger 3 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | 0.626 |
| LONRF3 | PRODH2 | ENSP00000360690 | ENSP00000301175 | LON peptidase N-terminal domain and ring finger 3 | Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp- trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis | 0.625 |
| LONRF3 | RNF149 | ENSP00000360690 | ENSP00000295317 | LON peptidase N-terminal domain and ring finger 3 | E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation; Ring finger proteins | 0.681 |
| LONRF3 | RNF32 | ENSP00000360690 | ENSP00000385285 | LON peptidase N-terminal domain and ring finger 3 | RING finger protein 32; May play a role in sperm formation; Ring finger proteins | 0.703 |
| LONRF3 | TBC1D8 | ENSP00000360690 | ENSP00000366036 | LON peptidase N-terminal domain and ring finger 3 | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s); GRAM domain containing | 0.694 |
| LONRF3 | TEX12 | ENSP00000360690 | ENSP00000280358 | LON peptidase N-terminal domain and ring finger 3 | Testis-expressed protein 12; Testis expressed 12 | 0.602 |
| LONRF3 | UBA52 | ENSP00000360690 | ENSP00000388107 | LON peptidase N-terminal domain and ring finger 3 | Ubiquitin-60S ribosomal protein L40; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be invo [...] | 0.728 |
| LONRF3 | ZCCHC18 | ENSP00000360690 | ENSP00000482195 | LON peptidase N-terminal domain and ring finger 3 | Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family | 0.656 |
| MTMR8 | EEPD1 | ENSP00000363985 | ENSP00000242108 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | Endonuclease/exonuclease/phosphatase family domain containing 1 | 0.567 |
| MTMR8 | LONRF3 | ENSP00000363985 | ENSP00000360690 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins | LON peptidase N-terminal domain and ring finger 3 | 0.626 |
| PRODH2 | LONRF3 | ENSP00000301175 | ENSP00000360690 | Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp- trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis | LON peptidase N-terminal domain and ring finger 3 | 0.625 |
| PRODH2 | TEX12 | ENSP00000301175 | ENSP00000280358 | Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp- trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis | Testis-expressed protein 12; Testis expressed 12 | 0.535 |
| RNF149 | IL1RAPL1 | ENSP00000295317 | ENSP00000368278 | E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation; Ring finger proteins | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family | 0.627 |
