• Version:
  • 11.0 [archived version]
STRINGSTRING
PDE6C PDE6C LGI1 LGI1 ZNF32 ZNF32 CWC27 CWC27 SPATA8 SPATA8 FRA10AC1 FRA10AC1 FAM46B FAM46B TMEM185A TMEM185A DGCR14 DGCR14 AFF2 AFF2 LENG1 LENG1
"FRA10AC1" - Protein FRA10AC1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FRA10AC1Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex (315 aa)    
Predicted Functional Partners:
ZNF32
Zinc finger protein 32; May be involved in transcriptional regulation; Zinc fingers C2H2-type (273 aa)
            
  0.901
DGCR14
Protein DGCR14; May be involved in pre-mRNA splicing (476 aa)
        
 
  0.828
LENG1
Leukocyte receptor cluster member 1; Spliceosomal C complex (264 aa)
        
      0.826
PDE6C
Cone cGMP-specific 3’,5’-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP; Phosphodiesterases (858 aa)
            
  0.803
TMEM185A
Transmembrane protein 185A; Belongs to the TMEM185 family (350 aa)
            
  0.725
AFF2
AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure; AF4/FMR2 family (1311 aa)
            
  0.720
LGI1
Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival (557 aa)
            
  0.719
CWC27
Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family (472 aa)
        
      0.710
FAM46B
Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase (425 aa)
        
      0.710
SPATA8
Spermatogenesis-associated protein 8; Spermatogenesis associated 8 (105 aa)
            
  0.669
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >