| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP1 | AKAP14 | ENSP00000478212 | ENSP00000360485 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | 0.753 |
| AKAP1 | AKAP4 | ENSP00000478212 | ENSP00000351327 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | 0.640 |
| AKAP1 | PRKACA | ENSP00000478212 | ENSP00000309591 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.952 |
| AKAP1 | PRKACB | ENSP00000478212 | ENSP00000359719 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.981 |
| AKAP1 | PRKACG | ENSP00000478212 | ENSP00000366488 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily | 0.973 |
| AKAP1 | PRKAR2A | ENSP00000478212 | ENSP00000265563 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.970 |
| AKAP1 | PRKAR2B | ENSP00000478212 | ENSP00000265717 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.982 |
| AKAP14 | AKAP1 | ENSP00000360485 | ENSP00000478212 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | 0.753 |
| AKAP14 | AKAP4 | ENSP00000360485 | ENSP00000351327 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | 0.860 |
| AKAP14 | HBE1 | ENSP00000360485 | ENSP00000369586 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family | 0.749 |
| AKAP14 | KIAA1210 | ENSP00000360485 | ENSP00000384670 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Acrosomal protein KIAA1210; KIAA1210 | 0.810 |
| AKAP14 | PRKACA | ENSP00000360485 | ENSP00000309591 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.962 |
| AKAP14 | PRKACB | ENSP00000360485 | ENSP00000359719 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.929 |
| AKAP14 | PRKACG | ENSP00000360485 | ENSP00000366488 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily | 0.795 |
| AKAP14 | PRKAR2A | ENSP00000360485 | ENSP00000265563 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.952 |
| AKAP14 | PRKAR2B | ENSP00000360485 | ENSP00000265717 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.807 |
| AKAP14 | SPA17 | ENSP00000360485 | ENSP00000432305 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.896 |
| AKAP4 | AKAP1 | ENSP00000351327 | ENSP00000478212 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | 0.640 |
| AKAP4 | AKAP14 | ENSP00000351327 | ENSP00000360485 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | 0.860 |
| AKAP4 | PRKACA | ENSP00000351327 | ENSP00000309591 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.901 |
