• Version:
  • 11.0 [archived version]
STRINGSTRING
TPTE2 TPTE2 MANSC1 MANSC1 OR10S1 OR10S1 MSANTD1 MSANTD1 TMEM59 TMEM59 SLCO1B7 SLCO1B7 LDLRAD1 LDLRAD1 LCE1A LCE1A AP3S2 AP3S2 FGFBP3 FGFBP3 TCEANC2 TCEANC2
"LDLRAD1" - Low density lipoprotein receptor class A domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LDLRAD1Low density lipoprotein receptor class A domain containing 1 (205 aa)    
Predicted Functional Partners:
OR10S1
Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 (331 aa)
           
  0.648
MSANTD1
Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1 (278 aa)
           
  0.587
MANSC1
MANSC domain containing 1 (431 aa)
           
  0.585
SLCO1B7
Solute carrier organic anion transporter family member 1B7 (640 aa)
           
  0.571
TCEANC2
Transcription elongation factor A N-terminal and central domain containing 2 (208 aa)
           
  0.570
LCE1A
Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum (110 aa)
           
  0.531
AP3S2
AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (193 aa)
           
  0.477
FGFBP3
Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability (258 aa)
           
  0.463
TMEM59
Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding; Belongs to the TMEM59 family (323 aa)
           
  0.450
TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; C2 tensin-type domain containing (522 aa)
           
  0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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