node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP3S2 | LDLRAD1 | ENSP00000338777 | ENSP00000360411 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | Low density lipoprotein receptor class A domain containing 1 | 0.477 |
AP3S2 | MSANTD1 | ENSP00000338777 | ENSP00000411584 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1 | 0.441 |
AP3S2 | OR10S1 | ENSP00000338777 | ENSP00000431914 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 | 0.475 |
AP3S2 | SLCO1B7 | ENSP00000338777 | ENSP00000394168 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | Solute carrier organic anion transporter family member 1B7 | 0.426 |
FGFBP3 | LDLRAD1 | ENSP00000339067 | ENSP00000360411 | Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability | Low density lipoprotein receptor class A domain containing 1 | 0.463 |
LCE1A | LDLRAD1 | ENSP00000334869 | ENSP00000360411 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum | Low density lipoprotein receptor class A domain containing 1 | 0.531 |
LCE1A | MSANTD1 | ENSP00000334869 | ENSP00000411584 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1 | 0.476 |
LCE1A | OR10S1 | ENSP00000334869 | ENSP00000431914 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum | Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 | 0.530 |
LCE1A | SLCO1B7 | ENSP00000334869 | ENSP00000394168 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum | Solute carrier organic anion transporter family member 1B7 | 0.459 |
LDLRAD1 | AP3S2 | ENSP00000360411 | ENSP00000338777 | Low density lipoprotein receptor class A domain containing 1 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals | 0.477 |
LDLRAD1 | FGFBP3 | ENSP00000360411 | ENSP00000339067 | Low density lipoprotein receptor class A domain containing 1 | Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability | 0.463 |
LDLRAD1 | LCE1A | ENSP00000360411 | ENSP00000334869 | Low density lipoprotein receptor class A domain containing 1 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum | 0.531 |
LDLRAD1 | MANSC1 | ENSP00000360411 | ENSP00000438205 | Low density lipoprotein receptor class A domain containing 1 | MANSC domain containing 1 | 0.585 |
LDLRAD1 | MSANTD1 | ENSP00000360411 | ENSP00000411584 | Low density lipoprotein receptor class A domain containing 1 | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1 | 0.587 |
LDLRAD1 | OR10S1 | ENSP00000360411 | ENSP00000431914 | Low density lipoprotein receptor class A domain containing 1 | Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 | 0.648 |
LDLRAD1 | SLCO1B7 | ENSP00000360411 | ENSP00000394168 | Low density lipoprotein receptor class A domain containing 1 | Solute carrier organic anion transporter family member 1B7 | 0.571 |
LDLRAD1 | TCEANC2 | ENSP00000360411 | ENSP00000234827 | Low density lipoprotein receptor class A domain containing 1 | Transcription elongation factor A N-terminal and central domain containing 2 | 0.570 |
LDLRAD1 | TMEM59 | ENSP00000360411 | ENSP00000234831 | Low density lipoprotein receptor class A domain containing 1 | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding; Belongs to the TMEM59 family | 0.450 |
LDLRAD1 | TPTE2 | ENSP00000360411 | ENSP00000383089 | Low density lipoprotein receptor class A domain containing 1 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; C2 tensin-type domain containing | 0.444 |
MANSC1 | LDLRAD1 | ENSP00000438205 | ENSP00000360411 | MANSC domain containing 1 | Low density lipoprotein receptor class A domain containing 1 | 0.585 |