FGGY protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FGGY

FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family (575 aa)

Predicted Functional Partners:

SHPK

0.759

CTNS

0.718

RBM33

0.699

ITPR2

0.694

DPP6

0.678

XYLB

0.673

USP24

0.658

MYSM1

0.653

POLD2

0.633

KIFAP3

0.587

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNS	FGGY	ENSP00000371294	ENSP00000360262	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	0.718
CTNS	SHPK	ENSP00000371294	ENSP00000225519	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism	0.906
DPP6	FGGY	ENSP00000367001	ENSP00000360262	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	0.678
DPP6	ITPR2	ENSP00000367001	ENSP00000370744	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated	0.520
DPP6	KIFAP3	ENSP00000367001	ENSP00000354560	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity); Armadillo-like helical domain containing	0.521
DPP6	RBM33	ENSP00000367001	ENSP00000384160	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	RNA-binding protein 33; RNA binding motif containing	0.443
DPP6	USP24	ENSP00000367001	ENSP00000294383	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	Ubiquitin carboxyl-terminal hydrolase 24; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation; Ubiquitin specific peptidases	0.449
FGGY	CTNS	ENSP00000360262	ENSP00000371294	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	0.718
FGGY	DPP6	ENSP00000360262	ENSP00000367001	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	0.678
FGGY	ITPR2	ENSP00000360262	ENSP00000370744	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated	0.694
FGGY	KIFAP3	ENSP00000360262	ENSP00000354560	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity); Armadillo-like helical domain containing	0.587
FGGY	MYSM1	ENSP00000360262	ENSP00000418734	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation; Myb/SANT domain containing	0.653
FGGY	POLD2	ENSP00000360262	ENSP00000480186	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	DNA polymerase delta subunit 2; As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol- delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this [...]	0.633
FGGY	RBM33	ENSP00000360262	ENSP00000384160	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	RNA-binding protein 33; RNA binding motif containing	0.699
FGGY	SHPK	ENSP00000360262	ENSP00000225519	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism	0.759
FGGY	USP24	ENSP00000360262	ENSP00000294383	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Ubiquitin carboxyl-terminal hydrolase 24; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation; Ubiquitin specific peptidases	0.658
FGGY	XYLB	ENSP00000360262	ENSP00000207870	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis	0.673
ITPR2	DPP6	ENSP00000370744	ENSP00000367001	Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated	Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity; DASH family	0.520
ITPR2	FGGY	ENSP00000370744	ENSP00000360262	Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	0.694
ITPR2	KIFAP3	ENSP00000370744	ENSP00000354560	Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated	Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity); Armadillo-like helical domain containing	0.482

page 1 of 2

Network

Fusion

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Neighborhood

© STRING Consortium 2020

Credits

Access

Info

About