TM9SF3 protein (human) - STRING database

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TM9SF3

Transmembrane 9 superfamily member 3 (589 aa)

Predicted Functional Partners:

TMED7

0.665

PGAP2

0.653

TAC1

0.625

ZFPL1

0.596

ENSG00000251201

0.583

FAF2

0.569

C12orf49

0.540

TRMT6

0.531

SMEK2

0.525

MRPL16

0.524

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf49	TM9SF3	ENSP00000261318	ENSP00000360184	UPF0454 protein C12orf49; Chromosome 12 open reading frame 49; Belongs to the UPF0454 family	Transmembrane 9 superfamily member 3	0.540
ENSG00000251201	TM9SF3	ENSP00000282382	ENSP00000360184	Transmembrane emp24 domain-containing protein 7; TMED7-TICAM2 readthrough	Transmembrane 9 superfamily member 3	0.583
FAF2	TM9SF3	ENSP00000261942	ENSP00000360184	FAS-associated factor 2; Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis; UBX domain containing	Transmembrane 9 superfamily member 3	0.569
MRPL16	PGAP2	ENSP00000300151	ENSP00000278243	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family	Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)	0.505
MRPL16	TM9SF3	ENSP00000300151	ENSP00000360184	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family	Transmembrane 9 superfamily member 3	0.524
MRPL16	TRMT6	ENSP00000300151	ENSP00000203001	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries	0.546
PGAP2	MRPL16	ENSP00000278243	ENSP00000300151	Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family	0.505
PGAP2	TM9SF3	ENSP00000278243	ENSP00000360184	Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)	Transmembrane 9 superfamily member 3	0.653
PGAP2	TRMT6	ENSP00000278243	ENSP00000203001	Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries	0.542
SMEK2	TM9SF3	ENSP00000483228	ENSP00000360184	Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers	Transmembrane 9 superfamily member 3	0.525
TAC1	TM9SF3	ENSP00000321106	ENSP00000360184	Protachykinin-1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Endogenous ligands	Transmembrane 9 superfamily member 3	0.625
TM9SF3	C12orf49	ENSP00000360184	ENSP00000261318	Transmembrane 9 superfamily member 3	UPF0454 protein C12orf49; Chromosome 12 open reading frame 49; Belongs to the UPF0454 family	0.540
TM9SF3	ENSG00000251201	ENSP00000360184	ENSP00000282382	Transmembrane 9 superfamily member 3	Transmembrane emp24 domain-containing protein 7; TMED7-TICAM2 readthrough	0.583
TM9SF3	FAF2	ENSP00000360184	ENSP00000261942	Transmembrane 9 superfamily member 3	FAS-associated factor 2; Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis; UBX domain containing	0.569
TM9SF3	MRPL16	ENSP00000360184	ENSP00000300151	Transmembrane 9 superfamily member 3	Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family	0.524
TM9SF3	PGAP2	ENSP00000360184	ENSP00000278243	Transmembrane 9 superfamily member 3	Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity)	0.653
TM9SF3	SMEK2	ENSP00000360184	ENSP00000483228	Transmembrane 9 superfamily member 3	Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers	0.525
TM9SF3	TAC1	ENSP00000360184	ENSP00000321106	Transmembrane 9 superfamily member 3	Protachykinin-1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Endogenous ligands	0.625
TM9SF3	TMED7	ENSP00000360184	ENSP00000405926	Transmembrane 9 superfamily member 3	Transmembrane emp24 domain-containing protein 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications; Transmembrane p24 trafficking proteins	0.665
TM9SF3	TRMT6	ENSP00000360184	ENSP00000203001	Transmembrane 9 superfamily member 3	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs- N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries	0.531

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