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  • 11.0 [archived version]
STRINGSTRING
FARP1 FARP1 DCAF8L1 DCAF8L1 DCAF12L2 DCAF12L2 TMEM95 TMEM95 DCAF8L2 DCAF8L2 DCAF12L1 DCAF12L1 SH2D2A SH2D2A TENM1 TENM1 AAED1 AAED1 LRRC57 LRRC57 PRR32 PRR32
"DCAF12L1" - DDB1- and CUL4-associated factor 12-like protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCAF12L1DDB1- and CUL4-associated factor 12-like protein 1; DDB1 and CUL4 associated factor 12 like 1; WD repeat domain containing (463 aa)    
Predicted Functional Partners:
DCAF8L1
DDB1- and CUL4-associated factor 8-like protein 1; DDB1 and CUL4 associated factor 8 like 1; Belongs to the WD repeat DCAF8 family (600 aa)
           
  0.684
DCAF8L2
DDB1- and CUL4-associated factor 8-like protein 2; DDB1 and CUL4 associated factor 8 like 2; Belongs to the WD repeat DCAF8 family (631 aa)
           
  0.665
TMEM95
Transmembrane protein 95 (184 aa)
           
  0.628
FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity); FERM domain containing (1076 aa)
           
  0.620
DCAF12L2
DDB1- and CUL4-associated factor 12-like protein 2; DDB1 and CUL4 associated factor 12 like 2; Belongs to the WD repeat DCAF12 family (463 aa)
     
 
0.561
TENM1
Teneurin-1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa)
     
        0.551
PRR32
Proline-rich protein 32; Proline rich 32 (298 aa)
           
  0.533
SH2D2A
SH2 domain-containing protein 2A; Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation; SH2 domain containing (399 aa)
       
 
  0.526
LRRC57
Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 (239 aa)
       
 
  0.516
AAED1
Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family (226 aa)
           
  0.513
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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