ACTRT1 protein (human) - STRING database

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ACTRT1

Actin related protein T1 (376 aa)

Predicted Functional Partners:

ADCY3

0.680

PRR32

0.646

RALY

0.618

LRRC39

0.607

PFN3

0.585

WSCD2

0.575

ASB17

0.574

FRYL

0.566

CCIN

0.566

SPACA5B

0.555

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTRT1	ADCY3	ENSP00000360165	ENSP00000260600	Actin related protein T1	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases	0.680
ACTRT1	ASB17	ENSP00000360165	ENSP00000284142	Actin related protein T1	Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing	0.574
ACTRT1	CCIN	ENSP00000360165	ENSP00000334996	Actin related protein T1	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	0.566
ACTRT1	FRYL	ENSP00000360165	ENSP00000351113	Actin related protein T1	Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator; Belongs to the furry protein family	0.566
ACTRT1	LRRC39	ENSP00000360165	ENSP00000480740	Actin related protein T1	Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart	0.607
ACTRT1	PFN3	ENSP00000360165	ENSP00000351379	Actin related protein T1	Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis; Belongs to the profilin family	0.585
ACTRT1	PRR32	ENSP00000360165	ENSP00000360166	Actin related protein T1	Proline-rich protein 32; Proline rich 32	0.646
ACTRT1	RALY	ENSP00000360165	ENSP00000246194	Actin related protein T1	RNA-binding protein Raly; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP); Belongs to the RRM HNRPC family. RALY subfamily	0.618
ACTRT1	SPACA5B	ENSP00000360165	ENSP00000304762	Actin related protein T1	Sperm acrosome associated 5B; Lysozymes, c-type	0.555
ACTRT1	WSCD2	ENSP00000360165	ENSP00000331933	Actin related protein T1	WSC domain containing 2; Belongs to the WSCD family	0.575
ADCY3	ACTRT1	ENSP00000260600	ENSP00000360165	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases	Actin related protein T1	0.680
ADCY3	RALY	ENSP00000260600	ENSP00000246194	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet; Adenylate cyclases	RNA-binding protein Raly; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP); Belongs to the RRM HNRPC family. RALY subfamily	0.547
ASB17	ACTRT1	ENSP00000284142	ENSP00000360165	Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Ankyrin repeat domain containing	Actin related protein T1	0.574
CCIN	ACTRT1	ENSP00000334996	ENSP00000360165	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	Actin related protein T1	0.566
FRYL	ACTRT1	ENSP00000351113	ENSP00000360165	Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator; Belongs to the furry protein family	Actin related protein T1	0.566
FRYL	LRRC39	ENSP00000351113	ENSP00000480740	Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator; Belongs to the furry protein family	Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart	0.543
FRYL	WSCD2	ENSP00000351113	ENSP00000331933	Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator; Belongs to the furry protein family	WSC domain containing 2; Belongs to the WSCD family	0.575
LRRC39	ACTRT1	ENSP00000480740	ENSP00000360165	Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart	Actin related protein T1	0.607
LRRC39	FRYL	ENSP00000480740	ENSP00000351113	Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart	Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator; Belongs to the furry protein family	0.543
LRRC39	WSCD2	ENSP00000480740	ENSP00000331933	Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart	WSC domain containing 2; Belongs to the WSCD family	0.585

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