node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | ALPL | ENSP00000295463 | ENSP00000363973 | Alkaline phosphatase, intestinal | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.905 |
ALPI | ALPPL2 | ENSP00000295463 | ENSP00000295453 | Alkaline phosphatase, intestinal | Alkaline phosphatase, placental like 2 | 0.968 |
ALPI | ART3 | ENSP00000295463 | ENSP00000348064 | Alkaline phosphatase, intestinal | ADP-ribosyltransferase 3 | 0.901 |
ALPI | CD52 | ENSP00000295463 | ENSP00000363330 | Alkaline phosphatase, intestinal | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | 0.901 |
ALPI | CPM | ENSP00000295463 | ENSP00000448517 | Alkaline phosphatase, intestinal | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | 0.900 |
ALPI | FOLR2 | ENSP00000295463 | ENSP00000298223 | Alkaline phosphatase, intestinal | Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release | 0.900 |
ALPI | TECTB | ENSP00000295463 | ENSP00000358430 | Alkaline phosphatase, intestinal | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.906 |
ALPI | VNN1 | ENSP00000295463 | ENSP00000356905 | Alkaline phosphatase, intestinal | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family | 0.901 |
ALPI | VNN2 | ENSP00000295463 | ENSP00000322276 | Alkaline phosphatase, intestinal | Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil; Vanins | 0.901 |
ALPI | XPNPEP2 | ENSP00000295463 | ENSP00000360147 | Alkaline phosphatase, intestinal | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.919 |
ALPL | ALPI | ENSP00000363973 | ENSP00000295463 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alkaline phosphatase, intestinal | 0.905 |
ALPL | ALPPL2 | ENSP00000363973 | ENSP00000295453 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alkaline phosphatase, placental like 2 | 0.903 |
ALPL | ART3 | ENSP00000363973 | ENSP00000348064 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | ADP-ribosyltransferase 3 | 0.902 |
ALPL | CD52 | ENSP00000363973 | ENSP00000363330 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | 0.902 |
ALPL | CPM | ENSP00000363973 | ENSP00000448517 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | 0.900 |
ALPL | FOLR2 | ENSP00000363973 | ENSP00000298223 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release | 0.900 |
ALPL | TECTB | ENSP00000363973 | ENSP00000358430 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.906 |
ALPL | VNN1 | ENSP00000363973 | ENSP00000356905 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family | 0.905 |
ALPL | VNN2 | ENSP00000363973 | ENSP00000322276 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil; Vanins | 0.901 |
ALPL | XPNPEP2 | ENSP00000363973 | ENSP00000360147 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.911 |