EFCAB7 protein (human) - STRING database

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EFCAB7

EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing (629 aa)

Predicted Functional Partners:

IQCE

0.987

EVC2

0.958

EVC

0.952

SPA17

0.827

CACHD1

0.789

TMEM125

0.776

KANK4

0.742

AKAP14

0.737

ALG6

0.666

CPSF2

0.645

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP14	EFCAB7	ENSP00000360485	ENSP00000360129	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	0.737
AKAP14	SPA17	ENSP00000360485	ENSP00000432305	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.896
ALG6	CACHD1	ENSP00000360149	ENSP00000290039	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	0.782
ALG6	EFCAB7	ENSP00000360149	ENSP00000360129	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	0.666
ALG6	KANK4	ENSP00000360149	ENSP00000360195	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing	0.717
ALG6	TMEM125	ENSP00000360149	ENSP00000429275	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	Transmembrane protein 125	0.739
CACHD1	ALG6	ENSP00000290039	ENSP00000360149	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	0.782
CACHD1	EFCAB7	ENSP00000290039	ENSP00000360129	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	0.789
CACHD1	KANK4	ENSP00000290039	ENSP00000360195	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing	0.807
CACHD1	TMEM125	ENSP00000290039	ENSP00000429275	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	Transmembrane protein 125	0.795
CPSF2	EFCAB7	ENSP00000298875	ENSP00000360129	Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	0.645
EFCAB7	AKAP14	ENSP00000360129	ENSP00000360485	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins	0.737
EFCAB7	ALG6	ENSP00000360129	ENSP00000360149	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol; Alpha-1,3-glucosyltransferases	0.666
EFCAB7	CACHD1	ENSP00000360129	ENSP00000290039	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels	0.789
EFCAB7	CPSF2	ENSP00000360129	ENSP00000298875	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing; Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily	0.645
EFCAB7	EVC	ENSP00000360129	ENSP00000264956	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	Ellis-van Creveld syndrome protein; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development	0.952
EFCAB7	EVC2	ENSP00000360129	ENSP00000342144	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis	0.958
EFCAB7	IQCE	ENSP00000360129	ENSP00000480715	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	0.987
EFCAB7	KANK4	ENSP00000360129	ENSP00000360195	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing	0.742
EFCAB7	SPA17	ENSP00000360129	ENSP00000432305	EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2-EVC subcomplex at the base of primary cilia; EF-hand domain containing	Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.827

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