PHACTR3 protein (human) - STRING database

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PHACTR3

Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators (559 aa)

Predicted Functional Partners:

PPP1CA

0.960

PPP1CB

0.942

BCAS4

0.703

PFDN4

0.691

RBM38

0.677

CTCFL

0.669

FAM19A4

0.630

FAM209B

0.560

CBLN4

0.544

EIF4ENIF1

0.540

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAS4	FAM209B	ENSP00000351642	ENSP00000360376	Breast carcinoma amplified sequence 4	Protein FAM209B; Family with sequence similarity 209 member B	0.549
BCAS4	PFDN4	ENSP00000351642	ENSP00000360473	Breast carcinoma amplified sequence 4	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family	0.400
BCAS4	PHACTR3	ENSP00000351642	ENSP00000360054	Breast carcinoma amplified sequence 4	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.703
CBLN4	CTCFL	ENSP00000064571	ENSP00000415579	Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)	Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ’Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...]	0.640
CBLN4	PHACTR3	ENSP00000064571	ENSP00000360054	Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.544
CBLN4	RBM38	ENSP00000064571	ENSP00000348538	Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)	RNA-binding protein 38; RNA-binding protein that specifically bind the 3’-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- I [...]	0.661
CTCFL	CBLN4	ENSP00000415579	ENSP00000064571	Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ’Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...]	Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)	0.640
CTCFL	PHACTR3	ENSP00000415579	ENSP00000360054	Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ’Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...]	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.669
CTCFL	RBM38	ENSP00000415579	ENSP00000348538	Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ’Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...]	RNA-binding protein 38; RNA-binding protein that specifically bind the 3’-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- I [...]	0.695
EIF4ENIF1	PHACTR3	ENSP00000380659	ENSP00000360054	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.540
FAM19A4	PHACTR3	ENSP00000295569	ENSP00000360054	Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.630
FAM209B	BCAS4	ENSP00000360376	ENSP00000351642	Protein FAM209B; Family with sequence similarity 209 member B	Breast carcinoma amplified sequence 4	0.549
FAM209B	PHACTR3	ENSP00000360376	ENSP00000360054	Protein FAM209B; Family with sequence similarity 209 member B	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.560
PFDN4	BCAS4	ENSP00000360473	ENSP00000351642	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family	Breast carcinoma amplified sequence 4	0.400
PFDN4	PHACTR3	ENSP00000360473	ENSP00000360054	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	0.691
PHACTR3	BCAS4	ENSP00000360054	ENSP00000351642	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	Breast carcinoma amplified sequence 4	0.703
PHACTR3	CBLN4	ENSP00000360054	ENSP00000064571	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity)	0.544
PHACTR3	CTCFL	ENSP00000360054	ENSP00000415579	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 ’Arg-3’ to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...]	0.669
PHACTR3	EIF4ENIF1	ENSP00000360054	ENSP00000380659	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	0.540
PHACTR3	FAM19A4	ENSP00000360054	ENSP00000295569	Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators	Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like	0.630

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