• Version:
  • 11.0 [archived version]
STRINGSTRING
ZAR1 ZAR1 KIAA0040 KIAA0040 NDUFC1 NDUFC1 SLC10A5 SLC10A5 HHLA3 HHLA3 KIF2B KIF2B HHLA2 HHLA2 HAPLN3 HAPLN3 KIAA2013 KIAA2013
"HHLA3" - HERV-H LTR-associating 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HHLA3HERV-H LTR-associating 3 (121 aa)    
Predicted Functional Partners:
HHLA2
HERV-H LTR-associating protein 2; Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade; C1-set domain containing (414 aa)
           
  0.931
KIAA0040
Uncharacterized protein KIAA0040; KIAA0040 (99 aa)
           
  0.530
SLC10A5
Sodium/bile acid cotransporter 5; Solute carrier family 10 member 5 (438 aa)
           
  0.520
HAPLN3
Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing (360 aa)
           
  0.450
NDUFC1
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone; NADH-ubiquinone oxidoreductase supernumerary subunits (76 aa)
           
  0.441
KIF2B
Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression; Kinesins (673 aa)
           
  0.440
KIAA2013
Uncharacterized protein KIAA2013; KIAA2013 (634 aa)
           
  0.416
ZAR1
Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type (424 aa)
           
  0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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