| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPL1 | GIPC2 | ENSP00000288266 | ENSP00000359795 | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.496 |
| APPL1 | NTRK1 | ENSP00000288266 | ENSP00000431418 | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Rec [...] | 0.489 |
| APPL1 | RGS19 | ENSP00000288266 | ENSP00000378483 | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein | 0.400 |
| FZD1 | FZD3 | ENSP00000287934 | ENSP00000437489 | Frizzled-1; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | 0.907 |
| FZD1 | GIPC2 | ENSP00000287934 | ENSP00000359795 | Frizzled-1; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.508 |
| FZD3 | FZD1 | ENSP00000437489 | ENSP00000287934 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | Frizzled-1; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | 0.907 |
| FZD3 | GIPC2 | ENSP00000437489 | ENSP00000359795 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.733 |
| GH2 | GIPC2 | ENSP00000333157 | ENSP00000359795 | Growth hormone 1 isoform 5; Growth hormone family; Endogenous ligands | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.514 |
| GIPC2 | APPL1 | ENSP00000359795 | ENSP00000288266 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway; BAR-PH domain containing | 0.496 |
| GIPC2 | FZD1 | ENSP00000359795 | ENSP00000287934 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Frizzled-1; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | 0.508 |
| GIPC2 | FZD3 | ENSP00000359795 | ENSP00000437489 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to [...] | 0.733 |
| GIPC2 | GH2 | ENSP00000359795 | ENSP00000333157 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Growth hormone 1 isoform 5; Growth hormone family; Endogenous ligands | 0.514 |
| GIPC2 | MYO5B | ENSP00000359795 | ENSP00000285039 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Unconventional myosin-Vb; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis; Belongs to the TRAFAC cla [...] | 0.493 |
| GIPC2 | MYO6 | ENSP00000359795 | ENSP00000358994 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated [...] | 0.853 |
| GIPC2 | NTRK1 | ENSP00000359795 | ENSP00000431418 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Rec [...] | 0.649 |
| GIPC2 | RGS19 | ENSP00000359795 | ENSP00000378483 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein | 0.676 |
| GIPC2 | RRAS | ENSP00000359795 | ENSP00000246792 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | Ras-related protein R-Ras; Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity; Belongs to the small GTPase superfamily. Ras family | 0.531 |
| GIPC2 | SH3BP4 | ENSP00000359795 | ENSP00000386862 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy | 0.573 |
| MYO5B | GIPC2 | ENSP00000285039 | ENSP00000359795 | Unconventional myosin-Vb; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis; Belongs to the TRAFAC cla [...] | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.493 |
| MYO6 | GIPC2 | ENSP00000358994 | ENSP00000359795 | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated [...] | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family | 0.853 |
