node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEND6 | KIAA1586 | ENSP00000359782 | ENSP00000359768 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins | 0.615 |
ENSG00000182974 | FAM89B | ENSP00000329467 | ENSP00000431459 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.527 |
ENSG00000182974 | FLYWCH1 | ENSP00000329467 | ENSP00000399938 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | FLYWCH-type zinc finger 1 | 0.558 |
ENSG00000182974 | KIAA1586 | ENSP00000329467 | ENSP00000359768 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins | 0.574 |
ENSG00000182974 | ODF3L2 | ENSP00000329467 | ENSP00000318029 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | Outer dense fiber of sperm tails 3 like 2 | 0.511 |
ENSG00000182974 | RNF133 | ENSP00000329467 | ENSP00000344489 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | 0.505 |
ENSG00000182974 | RNF148 | ENSP00000329467 | ENSP00000388207 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | Ring finger protein 148 | 0.483 |
ENSG00000274102 | FAM89B | ENSP00000483239 | ENSP00000431459 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.529 |
ENSG00000274102 | FLYWCH1 | ENSP00000483239 | ENSP00000399938 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | FLYWCH-type zinc finger 1 | 0.558 |
ENSG00000274102 | KIAA1586 | ENSP00000483239 | ENSP00000359768 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins | 0.577 |
ENSG00000274102 | ODF3L2 | ENSP00000483239 | ENSP00000318029 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | Outer dense fiber of sperm tails 3 like 2 | 0.511 |
ENSG00000274102 | RNF133 | ENSP00000483239 | ENSP00000344489 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | 0.509 |
ENSG00000274102 | RNF148 | ENSP00000483239 | ENSP00000388207 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 | Ring finger protein 148 | 0.485 |
ENSG00000274792 | FAM89B | ENSP00000480318 | ENSP00000431459 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.511 |
ENSG00000274792 | FLYWCH1 | ENSP00000480318 | ENSP00000399938 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | FLYWCH-type zinc finger 1 | 0.550 |
ENSG00000274792 | KIAA1586 | ENSP00000480318 | ENSP00000359768 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins | 0.560 |
ENSG00000274792 | ODF3L2 | ENSP00000480318 | ENSP00000318029 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | Outer dense fiber of sperm tails 3 like 2 | 0.491 |
ENSG00000274792 | RNF133 | ENSP00000480318 | ENSP00000344489 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins | 0.485 |
ENSG00000274792 | RNF148 | ENSP00000480318 | ENSP00000388207 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 | Ring finger protein 148 | 0.457 |
FAM89B | ENSG00000182974 | ENSP00000431459 | ENSP00000329467 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 | 0.527 |