• Version:
  • 11.0 [archived version]
STRINGSTRING
ENSG00000274102 ENSG00000274102 RNF148 RNF148 FLYWCH1 FLYWCH1 RNF133 RNF133 ENSG00000274792 ENSG00000274792 FAM89B FAM89B ODF3L2 ODF3L2 ENSG00000182974 ENSG00000182974 KIAA1586 KIAA1586 OR1C1 OR1C1 BEND6 BEND6
"KIAA1586" - E3 SUMO-protein ligase KIAA1586 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1586E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins (787 aa)    
Predicted Functional Partners:
FLYWCH1
FLYWCH-type zinc finger 1 (715 aa)
           
  0.652
OR1C1
Olfactory receptor 1C1; Odorant receptor; Olfactory receptors, family 1 (314 aa)
           
  0.621
BEND6
BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing (279 aa)
           
  0.615
FAM89B
Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family (189 aa)
           
  0.587
ODF3L2
Outer dense fiber of sperm tails 3 like 2 (289 aa)
           
  0.582
RNF133
E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins (376 aa)
       
 
  0.581
ENSG00000274102
Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 (313 aa)
           
  0.577
ENSG00000182974
Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 (313 aa)
           
  0.574
RNF148
Ring finger protein 148 (305 aa)
       
 
  0.563
ENSG00000274792
Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 (316 aa)
           
  0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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