SAMD13 protein (human) - STRING database

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SAMD13

Sterile alpha motif domain containing 13 (116 aa)

Predicted Functional Partners:

L3MBTL3

0.685

STPG2

0.540

TMEM97

0.517

GAS7

0.508

LRRC6

0.483

PRKACB

0.444

MAML2

0.429

KLF12

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAS7	SAMD13	ENSP00000407552	ENSP00000359707	Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons; F-BAR domain containing	Sterile alpha motif domain containing 13	0.508
GAS7	TMEM97	ENSP00000407552	ENSP00000226230	Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons; F-BAR domain containing	Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins	0.456
KLF12	SAMD13	ENSP00000366897	ENSP00000359707	Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family	Sterile alpha motif domain containing 13	0.414
L3MBTL3	SAMD13	ENSP00000431962	ENSP00000359707	Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity); MBT domain containing	Sterile alpha motif domain containing 13	0.685
LRRC6	SAMD13	ENSP00000484634	ENSP00000359707	Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility	Sterile alpha motif domain containing 13	0.483
LRRC6	STPG2	ENSP00000484634	ENSP00000295268	Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility	Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2	0.451
MAML2	SAMD13	ENSP00000434552	ENSP00000359707	Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family	Sterile alpha motif domain containing 13	0.429
PRKACB	SAMD13	ENSP00000359719	ENSP00000359707	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	Sterile alpha motif domain containing 13	0.444
SAMD13	GAS7	ENSP00000359707	ENSP00000407552	Sterile alpha motif domain containing 13	Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons; F-BAR domain containing	0.508
SAMD13	KLF12	ENSP00000359707	ENSP00000366897	Sterile alpha motif domain containing 13	Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc-finger protein family	0.414
SAMD13	L3MBTL3	ENSP00000359707	ENSP00000431962	Sterile alpha motif domain containing 13	Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity); MBT domain containing	0.685
SAMD13	LRRC6	ENSP00000359707	ENSP00000484634	Sterile alpha motif domain containing 13	Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility	0.483
SAMD13	MAML2	ENSP00000359707	ENSP00000434552	Sterile alpha motif domain containing 13	Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3; Belongs to the mastermind family	0.429
SAMD13	PRKACB	ENSP00000359707	ENSP00000359719	Sterile alpha motif domain containing 13	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.444
SAMD13	STPG2	ENSP00000359707	ENSP00000295268	Sterile alpha motif domain containing 13	Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2	0.540
SAMD13	TMEM97	ENSP00000359707	ENSP00000226230	Sterile alpha motif domain containing 13	Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins	0.517
STPG2	LRRC6	ENSP00000295268	ENSP00000484634	Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2	Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility	0.451
STPG2	SAMD13	ENSP00000295268	ENSP00000359707	Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2	Sterile alpha motif domain containing 13	0.540
TMEM97	GAS7	ENSP00000226230	ENSP00000407552	Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins	Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons; F-BAR domain containing	0.456
TMEM97	SAMD13	ENSP00000226230	ENSP00000359707	Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins	Sterile alpha motif domain containing 13	0.517

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