| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf174 | CRTAC1 | ENSP00000451768 | ENSP00000359629 | Protein SOGA3; SOGA family member 3 | Cartilage acidic protein 1 | 0.552 |
| CRTAC1 | C6orf174 | ENSP00000359629 | ENSP00000451768 | Cartilage acidic protein 1 | Protein SOGA3; SOGA family member 3 | 0.552 |
| CRTAC1 | DGKH | ENSP00000359629 | ENSP00000337572 | Cartilage acidic protein 1 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | 0.514 |
| CRTAC1 | ENSG00000214338 | ENSP00000359629 | ENSP00000434570 | Cartilage acidic protein 1 | SOGA family member 3 | 0.529 |
| CRTAC1 | GOLGA7B | ENSP00000359629 | ENSP00000359634 | Cartilage acidic protein 1 | Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family | 0.590 |
| CRTAC1 | GPLD1 | ENSP00000359629 | ENSP00000230036 | Cartilage acidic protein 1 | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | 0.637 |
| CRTAC1 | IDI1 | ENSP00000359629 | ENSP00000370748 | Cartilage acidic protein 1 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.640 |
| CRTAC1 | MAPRE2 | ENSP00000359629 | ENSP00000300249 | Cartilage acidic protein 1 | Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity); Belongs to the MAPRE family | 0.787 |
| CRTAC1 | MAPRE3 | ENSP00000359629 | ENSP00000233121 | Cartilage acidic protein 1 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization- interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] | 0.780 |
| CRTAC1 | RGS4 | ENSP00000359629 | ENSP00000397181 | Cartilage acidic protein 1 | Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein | 0.532 |
| CRTAC1 | UBE2I | ENSP00000359629 | ENSP00000348056 | Cartilage acidic protein 1 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’; Belongs to the ubiquitin-conjugating enzyme family | 0.797 |
| DGKH | CRTAC1 | ENSP00000337572 | ENSP00000359629 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Cartilage acidic protein 1 | 0.514 |
| DGKH | IDI1 | ENSP00000337572 | ENSP00000370748 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.400 |
| DGKH | RGS4 | ENSP00000337572 | ENSP00000397181 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein | 0.531 |
| ENSG00000214338 | CRTAC1 | ENSP00000434570 | ENSP00000359629 | SOGA family member 3 | Cartilage acidic protein 1 | 0.529 |
| GOLGA7B | CRTAC1 | ENSP00000359634 | ENSP00000359629 | Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family | Cartilage acidic protein 1 | 0.590 |
| GPLD1 | CRTAC1 | ENSP00000230036 | ENSP00000359629 | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | Cartilage acidic protein 1 | 0.637 |
| IDI1 | CRTAC1 | ENSP00000370748 | ENSP00000359629 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | Cartilage acidic protein 1 | 0.640 |
| IDI1 | DGKH | ENSP00000370748 | ENSP00000337572 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization | 0.400 |
| MAPRE2 | CRTAC1 | ENSP00000300249 | ENSP00000359629 | Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity); Belongs to the MAPRE family | Cartilage acidic protein 1 | 0.787 |
