node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2 | PYROXD2 | ENSP00000231420 | ENSP00000359607 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.585 |
APPBP2 | PYROXD2 | ENSP00000083182 | ENSP00000359607 | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.723 |
ARHGEF38 | ETNPPL | ENSP00000416125 | ENSP00000296486 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.514 |
ARHGEF38 | FAM115C | ENSP00000416125 | ENSP00000412724 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | 0.550 |
ARHGEF38 | PYROXD2 | ENSP00000416125 | ENSP00000359607 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.580 |
ARHGEF38 | UGT3A1 | ENSP00000416125 | ENSP00000274278 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family | 0.501 |
ETNPPL | ARHGEF38 | ENSP00000296486 | ENSP00000416125 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | 0.514 |
ETNPPL | FAM115C | ENSP00000296486 | ENSP00000412724 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | 0.415 |
ETNPPL | PYROXD2 | ENSP00000296486 | ENSP00000359607 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.546 |
FAM115C | ARHGEF38 | ENSP00000412724 | ENSP00000416125 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | 0.550 |
FAM115C | ETNPPL | ENSP00000412724 | ENSP00000296486 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.415 |
FAM115C | PYROXD2 | ENSP00000412724 | ENSP00000359607 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.537 |
FAM115C | UGT3A1 | ENSP00000412724 | ENSP00000274278 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family | 0.428 |
FDFT1 | PYROXD2 | ENSP00000480828 | ENSP00000359607 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.604 |
NAT8 | PYROXD2 | ENSP00000272425 | ENSP00000359607 | N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various protei [...] | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | 0.654 |
PYROXD2 | AGXT2 | ENSP00000359607 | ENSP00000231420 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.585 |
PYROXD2 | APPBP2 | ENSP00000359607 | ENSP00000083182 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.723 |
PYROXD2 | ARHGEF38 | ENSP00000359607 | ENSP00000416125 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing | 0.580 |
PYROXD2 | ETNPPL | ENSP00000359607 | ENSP00000296486 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde | 0.546 |
PYROXD2 | FAM115C | ENSP00000359607 | ENSP00000412724 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | 0.537 |