node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLCA1 | CLCA2 | ENSP00000234701 | ENSP00000359596 | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.907 |
CLCA1 | CLCA4 | ENSP00000234701 | ENSP00000359594 | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | 0.920 |
CLCA1 | ESAM | ENSP00000234701 | ENSP00000278927 | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.527 |
CLCA2 | CLCA1 | ENSP00000359596 | ENSP00000234701 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | 0.907 |
CLCA2 | CLCA4 | ENSP00000359596 | ENSP00000359594 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | 0.910 |
CLCA2 | DSC3 | ENSP00000359596 | ENSP00000353608 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | 0.500 |
CLCA2 | ESAM | ENSP00000359596 | ENSP00000278927 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.751 |
CLCA2 | ITGB4 | ENSP00000359596 | ENSP00000200181 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6-ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6-ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling | 0.530 |
CLCA2 | KCNK17 | ENSP00000359596 | ENSP00000362328 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K | 0.488 |
CLCA2 | KCTD20 | ENSP00000359596 | ENSP00000362836 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members | 0.682 |
CLCA2 | PRR16 | ENSP00000359596 | ENSP00000385118 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | 0.641 |
CLCA2 | SERPINB13 | ENSP00000359596 | ENSP00000341584 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Serpin B13; May play a role in the proliferation or differentiation of keratinocytes; Belongs to the serpin family. Ov-serpin subfamily | 0.485 |
CLCA2 | SPRR1B | ENSP00000359596 | ENSP00000306461 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.522 |
CLCA4 | CLCA1 | ENSP00000359594 | ENSP00000234701 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | 0.920 |
CLCA4 | CLCA2 | ENSP00000359594 | ENSP00000359596 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.910 |
DSC3 | CLCA2 | ENSP00000353608 | ENSP00000359596 | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.500 |
DSC3 | SPRR1B | ENSP00000353608 | ENSP00000306461 | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms; Desmosomal cadherins | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | 0.930 |
ESAM | CLCA1 | ENSP00000278927 | ENSP00000234701 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC; Chloride channel accessory | 0.527 |
ESAM | CLCA2 | ENSP00000278927 | ENSP00000359596 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.751 |
ITGB4 | CLCA2 | ENSP00000200181 | ENSP00000359596 | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6-ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6-ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family | 0.530 |