| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COQ5 | CXorf66 | ENSP00000288532 | ENSP00000359571 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2); Seven-beta-strand methyltransferase motif containing | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.511 |
| CXorf36 | CXorf66 | ENSP00000381086 | ENSP00000359571 | Deleted in autism-related protein 1; Chromosome X open reading frame 36 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.655 |
| CXorf66 | COQ5 | ENSP00000359571 | ENSP00000288532 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2); Seven-beta-strand methyltransferase motif containing | 0.511 |
| CXorf66 | CXorf36 | ENSP00000359571 | ENSP00000381086 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Deleted in autism-related protein 1; Chromosome X open reading frame 36 | 0.655 |
| CXorf66 | DOCK9 | ENSP00000359571 | ENSP00000365643 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Dedicator of cytokinesis protein 9; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation; Belongs to the DOCK family | 0.474 |
| CXorf66 | GPR64 | ENSP00000359571 | ENSP00000369198 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis | 0.450 |
| CXorf66 | GPX4 | ENSP00000359571 | ENSP00000346103 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | 0.440 |
| CXorf66 | POMGNT1 | ENSP00000359571 | ENSP00000361060 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity; Belongs to the glycosyltransferase 13 family | 0.797 |
| CXorf66 | SELK | ENSP00000359571 | ENSP00000418813 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from E [...] | 0.440 |
| DOCK9 | CXorf66 | ENSP00000365643 | ENSP00000359571 | Dedicator of cytokinesis protein 9; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation; Belongs to the DOCK family | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.474 |
| GPR64 | CXorf66 | ENSP00000369198 | ENSP00000359571 | Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.450 |
| GPX4 | CXorf66 | ENSP00000346103 | ENSP00000359571 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.440 |
| GPX4 | SELK | ENSP00000346103 | ENSP00000418813 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from E [...] | 0.711 |
| POMGNT1 | CXorf66 | ENSP00000361060 | ENSP00000359571 | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity; Belongs to the glycosyltransferase 13 family | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.797 |
| SELK | CXorf66 | ENSP00000418813 | ENSP00000359571 | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from E [...] | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 | 0.440 |
| SELK | GPX4 | ENSP00000418813 | ENSP00000346103 | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from E [...] | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] | 0.711 |
