node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLIC1 | LDOC1 | ENSP00000364935 | ENSP00000359557 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.510 |
CLIC1 | TPRKB | ENSP00000364935 | ENSP00000272424 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity); Belongs to the CGI121/TPRKB family | 0.595 |
FTH1 | LDOC1 | ENSP00000273550 | ENSP00000359557 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.557 |
GNL3L | LDOC1 | ENSP00000338573 | ENSP00000359557 | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.635 |
LDOC1 | CLIC1 | ENSP00000359557 | ENSP00000364935 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | 0.510 |
LDOC1 | FTH1 | ENSP00000359557 | ENSP00000273550 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family | 0.557 |
LDOC1 | GNL3L | ENSP00000359557 | ENSP00000338573 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | 0.635 |
LDOC1 | MZF1 | ENSP00000359557 | ENSP00000215057 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Myeloid zinc finger 1; Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.489 |
LDOC1 | PEG10 | ENSP00000359557 | ENSP00000418944 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5’-GCCTGTCTTT-3’ DNA sequence of the MB1 domain in the myelin basic protein (M [...] | 0.625 |
LDOC1 | PNMA5 | ENSP00000359557 | ENSP00000388850 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.600 |
LDOC1 | RGAG1 | ENSP00000359557 | ENSP00000419786 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 | 0.602 |
LDOC1 | SPANXD | ENSP00000359557 | ENSP00000359546 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family | 0.471 |
LDOC1 | TPRKB | ENSP00000359557 | ENSP00000272424 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity); Belongs to the CGI121/TPRKB family | 0.566 |
LDOC1 | ZCCHC16 | ENSP00000359557 | ENSP00000340590 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system | 0.596 |
MZF1 | LDOC1 | ENSP00000215057 | ENSP00000359557 | Myeloid zinc finger 1; Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development; Belongs to the krueppel C2H2-type zinc-finger protein family | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.489 |
PEG10 | LDOC1 | ENSP00000418944 | ENSP00000359557 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5’-GCCTGTCTTT-3’ DNA sequence of the MB1 domain in the myelin basic protein (M [...] | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.625 |
PEG10 | PNMA5 | ENSP00000418944 | ENSP00000388850 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5’-GCCTGTCTTT-3’ DNA sequence of the MB1 domain in the myelin basic protein (M [...] | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.658 |
PNMA5 | LDOC1 | ENSP00000388850 | ENSP00000359557 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family | 0.600 |
PNMA5 | PEG10 | ENSP00000388850 | ENSP00000418944 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5’-GCCTGTCTTT-3’ DNA sequence of the MB1 domain in the myelin basic protein (M [...] | 0.658 |
PNMA5 | RGAG1 | ENSP00000388850 | ENSP00000419786 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 | 0.466 |