SPANXA2 protein (human) - STRING database

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Score

SPANXA2

SPANX family member A2 (97 aa)

Predicted Functional Partners:

SPANXN4

0.808

SPANXA1

0.771

AKAP4

0.719

TSN

0.712

LGALS4

0.710

CT45A1

0.677

MAGEA1

0.614

XAGE1A

0.608

XAGE1B

0.602

CTAG1A

0.584

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP4	SPANXA1	ENSP00000351327	ENSP00000359550	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	Sperm protein associated with the nucleus, X-linked, family member A1; Belongs to the SPAN-X family	0.719
AKAP4	SPANXA2	ENSP00000351327	ENSP00000359549	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	SPANX family member A2	0.719
AKAP4	TSN	ENSP00000351327	ENSP00000374332	A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins	Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots; Belongs to the translin family	0.751
CT45A1	CTAG1A	ENSP00000470185	ENSP00000469441	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	0.605
CT45A1	MAGEA1	ENSP00000470185	ENSP00000349085	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family	0.589
CT45A1	SPANXA1	ENSP00000470185	ENSP00000359550	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	Sperm protein associated with the nucleus, X-linked, family member A1; Belongs to the SPAN-X family	0.677
CT45A1	SPANXA2	ENSP00000470185	ENSP00000359549	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	SPANX family member A2	0.677
CT45A1	SPANXN4	ENSP00000470185	ENSP00000405210	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family	0.450
CT45A1	XAGE1A	ENSP00000470185	ENSP00000364752	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	X antigen family member 1A	0.677
CT45A1	XAGE1B	ENSP00000470185	ENSP00000364766	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	X antigen family member 1B; Belongs to the GAGE family	0.680
CTAG1A	CT45A1	ENSP00000469441	ENSP00000470185	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	0.605
CTAG1A	MAGEA1	ENSP00000469441	ENSP00000349085	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family	0.865
CTAG1A	SPANXA1	ENSP00000469441	ENSP00000359550	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Sperm protein associated with the nucleus, X-linked, family member A1; Belongs to the SPAN-X family	0.575
CTAG1A	SPANXA2	ENSP00000469441	ENSP00000359549	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	SPANX family member A2	0.584
CTAG1A	XAGE1A	ENSP00000469441	ENSP00000364752	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	X antigen family member 1A	0.678
CTAG1A	XAGE1B	ENSP00000469441	ENSP00000364766	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	X antigen family member 1B; Belongs to the GAGE family	0.679
LGALS4	SPANXA1	ENSP00000302100	ENSP00000359550	Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins	Sperm protein associated with the nucleus, X-linked, family member A1; Belongs to the SPAN-X family	0.710
LGALS4	SPANXA2	ENSP00000302100	ENSP00000359549	Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins	SPANX family member A2	0.710
MAGEA1	CT45A1	ENSP00000349085	ENSP00000470185	Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family	Cancer/testis antigen family 45 member A1; Belongs to the CT45 family	0.589
MAGEA1	CTAG1A	ENSP00000349085	ENSP00000469441	Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	0.865

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