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STRINGSTRING
LHX9 LHX9 LHX2 LHX2 ATOH7 ATOH7 BARHL2 BARHL2 NEUROD4 NEUROD4 ISL1 ISL1 FOXN4 FOXN4 LHX1 LHX1 LHX5 LHX5 PTF1A PTF1A BHLHE22 BHLHE22
"BARHL2" - BarH-like 2 homeobox protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BARHL2BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes; NKL subclass homeoboxes and pseudogenes (387 aa)    
Predicted Functional Partners:
FOXN4
Forkhead box protein N4; Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5’-ACGC-3’. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 pr [...] (517 aa)
      
 
  0.735
BHLHE22
Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] (381 aa)
      
   
  0.699
NEUROD4
Neurogenic differentiation factor 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina (By similarity); Basic helix-loop-helix proteins (331 aa)
      
   
  0.635
LHX2
LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity); LIM class homeoboxes (406 aa)
      
 
  0.604
PTF1A
Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5’-CANNTG-3’. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] (328 aa)
      
 
  0.603
LHX5
LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system; LIM class homeoboxes (402 aa)
      
 
  0.602
ATOH7
Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells; Basic helix-loop-helix proteins (152 aa)
      
   
  0.599
LHX1
LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes (406 aa)
      
 
  0.595
ISL1
Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5’-ATAATTAA-3’ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] (349 aa)
      
 
  0.589
LHX9
LIM/homeobox protein Lhx9; Involved in gonadal development; LIM class homeoboxes (397 aa)
      
 
  0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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