| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC180 | FAM92A1 | ENSP00000434727 | ENSP00000429367 | Coiled-coil domain containing 180 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | 0.629 |
| CCDC180 | FRMD4B | ENSP00000434727 | ENSP00000381549 | Coiled-coil domain containing 180 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | 0.470 |
| CCDC180 | OGFRL1 | ENSP00000434727 | ENSP00000359464 | Coiled-coil domain containing 180 | Opioid growth factor receptor like 1 | 0.556 |
| CCDC180 | ZNF345 | ENSP00000434727 | ENSP00000431202 | Coiled-coil domain containing 180 | Zinc finger protein 345; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
| EEF2K | IVNS1ABP | ENSP00000263026 | ENSP00000356468 | Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced | Influenza virus NS1A-binding protein; Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may [...] | 0.456 |
| EEF2K | OGFRL1 | ENSP00000263026 | ENSP00000359464 | Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced | Opioid growth factor receptor like 1 | 0.494 |
| ENSG00000197054 | OGFRL1 | ENSP00000467286 | ENSP00000359464 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Opioid growth factor receptor like 1 | 0.473 |
| FAM92A1 | CCDC180 | ENSP00000429367 | ENSP00000434727 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | Coiled-coil domain containing 180 | 0.629 |
| FAM92A1 | FRMD4B | ENSP00000429367 | ENSP00000381549 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | 0.517 |
| FAM92A1 | OGFRL1 | ENSP00000429367 | ENSP00000359464 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | Opioid growth factor receptor like 1 | 0.621 |
| FAM92A1 | ZNF345 | ENSP00000429367 | ENSP00000431202 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | Zinc finger protein 345; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.549 |
| FRMD4B | CCDC180 | ENSP00000381549 | ENSP00000434727 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | Coiled-coil domain containing 180 | 0.470 |
| FRMD4B | FAM92A1 | ENSP00000381549 | ENSP00000429367 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis | 0.517 |
| FRMD4B | OGFRL1 | ENSP00000381549 | ENSP00000359464 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | Opioid growth factor receptor like 1 | 0.476 |
| FRMD4B | ZNF345 | ENSP00000381549 | ENSP00000431202 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | Zinc finger protein 345; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.442 |
| IGFBPL1 | INSL6 | ENSP00000366923 | ENSP00000371054 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | 0.463 |
| IGFBPL1 | OGFRL1 | ENSP00000366923 | ENSP00000359464 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | Opioid growth factor receptor like 1 | 0.474 |
| INSL6 | IGFBPL1 | ENSP00000371054 | ENSP00000366923 | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein; I-set domain containing | 0.463 |
| INSL6 | OGFRL1 | ENSP00000371054 | ENSP00000359464 | Insulin-like peptide INSL6; May have a role in sperm development and fertilization | Opioid growth factor receptor like 1 | 0.474 |
| IVNS1ABP | EEF2K | ENSP00000356468 | ENSP00000263026 | Influenza virus NS1A-binding protein; Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may [...] | Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced | 0.456 |
