EPHX4 protein (human) - STRING database

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EPHX4

Epoxide hydrolase 4; Abhydrolase domain containing (362 aa)

Predicted Functional Partners:

OCIAD2

0.694

KSR1

0.661

TREML1

0.650

EPHX1

0.597

RAPGEF1

0.586

TXNDC16

0.583

OLFM2

0.581

PAPLN

0.561

FAM134B

0.534

ACAD10

0.500

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAD10	EPHX4	ENSP00000389813	ENSP00000359410	Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA	Epoxide hydrolase 4; Abhydrolase domain containing	0.500
EPHX1	EPHX4	ENSP00000480004	ENSP00000359410	Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids	Epoxide hydrolase 4; Abhydrolase domain containing	0.597
EPHX4	ACAD10	ENSP00000359410	ENSP00000389813	Epoxide hydrolase 4; Abhydrolase domain containing	Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA	0.500
EPHX4	EPHX1	ENSP00000359410	ENSP00000480004	Epoxide hydrolase 4; Abhydrolase domain containing	Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids	0.597
EPHX4	FAM134B	ENSP00000359410	ENSP00000304642	Epoxide hydrolase 4; Abhydrolase domain containing	Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons	0.534
EPHX4	KSR1	ENSP00000359410	ENSP00000381958	Epoxide hydrolase 4; Abhydrolase domain containing	Kinase suppressor of Ras 1; Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself	0.661
EPHX4	OCIAD2	ENSP00000359410	ENSP00000423014	Epoxide hydrolase 4; Abhydrolase domain containing	OCIA domain containing 2	0.694
EPHX4	OLFM2	ENSP00000359410	ENSP00000264833	Epoxide hydrolase 4; Abhydrolase domain containing	Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs underg [...]	0.581
EPHX4	PAPLN	ENSP00000359410	ENSP00000345395	Epoxide hydrolase 4; Abhydrolase domain containing	Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family	0.561
EPHX4	RAPGEF1	ENSP00000359410	ENSP00000361263	Epoxide hydrolase 4; Abhydrolase domain containing	Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth	0.586
EPHX4	TREML1	ENSP00000359410	ENSP00000402855	Epoxide hydrolase 4; Abhydrolase domain containing	Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing	0.650
EPHX4	TXNDC16	ENSP00000359410	ENSP00000281741	Epoxide hydrolase 4; Abhydrolase domain containing	Thioredoxin domain containing 16	0.583
FAM134B	EPHX4	ENSP00000304642	ENSP00000359410	Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons	Epoxide hydrolase 4; Abhydrolase domain containing	0.534
FAM134B	OCIAD2	ENSP00000304642	ENSP00000423014	Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons	OCIA domain containing 2	0.461
KSR1	EPHX4	ENSP00000381958	ENSP00000359410	Kinase suppressor of Ras 1; Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself	Epoxide hydrolase 4; Abhydrolase domain containing	0.661
KSR1	RAPGEF1	ENSP00000381958	ENSP00000361263	Kinase suppressor of Ras 1; Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself	Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth	0.584
OCIAD2	EPHX4	ENSP00000423014	ENSP00000359410	OCIA domain containing 2	Epoxide hydrolase 4; Abhydrolase domain containing	0.694
OCIAD2	FAM134B	ENSP00000423014	ENSP00000304642	OCIA domain containing 2	Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons	0.461
OCIAD2	OLFM2	ENSP00000423014	ENSP00000264833	OCIA domain containing 2	Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs underg [...]	0.508
OCIAD2	PAPLN	ENSP00000423014	ENSP00000345395	OCIA domain containing 2	Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family	0.500

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