node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOT1 | ACOT2 | ENSP00000311224 | ENSP00000238651 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | 0.962 |
ACOT1 | ACOT4 | ENSP00000311224 | ENSP00000323071 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | 0.824 |
ACOT1 | FADS2 | ENSP00000311224 | ENSP00000278840 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | 0.433 |
ACOT1 | SCD | ENSP00000311224 | ENSP00000359380 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16-1 and 18-1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...] | 0.927 |
ACOT2 | ACOT1 | ENSP00000238651 | ENSP00000311224 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | 0.962 |
ACOT2 | ACOT4 | ENSP00000238651 | ENSP00000323071 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | 0.911 |
ACOT2 | SCD | ENSP00000238651 | ENSP00000359380 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16-1 and 18-1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...] | 0.911 |
ACOT4 | ACOT1 | ENSP00000323071 | ENSP00000311224 | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | 0.824 |
ACOT4 | ACOT2 | ENSP00000323071 | ENSP00000238651 | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs | 0.911 |
ACOT4 | FADS2 | ENSP00000323071 | ENSP00000278840 | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | 0.586 |
ACOT4 | SCD | ENSP00000323071 | ENSP00000359380 | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16-1 and 18-1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...] | 0.918 |
CYB5A | SCD | ENSP00000341625 | ENSP00000359380 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16-1 and 18-1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...] | 0.905 |
FADS1 | FADS2 | ENSP00000322229 | ENSP00000278840 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | 0.669 |
FADS1 | FASN | ENSP00000322229 | ENSP00000304592 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein; Seven-beta-strand methyltransferase motif containing | 0.633 |
FADS1 | SCD | ENSP00000322229 | ENSP00000359380 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16-1 and 18-1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By simi [...] | 0.890 |
FADS1 | SREBF1 | ENSP00000322229 | ENSP00000348069 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | Sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’); Basic helix-loop-helix proteins | 0.622 |
FADS2 | ACOT1 | ENSP00000278840 | ENSP00000311224 | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity) | 0.433 |
FADS2 | ACOT4 | ENSP00000278840 | ENSP00000323071 | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs; Belongs to the C/M/P thioester hydrolase family | 0.586 |
FADS2 | FADS1 | ENSP00000278840 | ENSP00000322229 | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20-3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20-3n-6) and eicosatetraenoic acid (20-4n-3) to generate arachidonic acid (AA) (20-4n-6) and eicosapentaenoic acid (EPA)(20-5n-3), [...] | 0.669 |
FADS2 | FASN | ENSP00000278840 | ENSP00000304592 | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18-2n-6) and alpha-linolenic acid (ALA) (18-3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18-2n-6) and ALA (18-3n-3) into gamma- linoleic acid (GLA) (18-3n-6) and stearidonic acid (18-4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It cat [...] | Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein; Seven-beta-strand methyltransferase motif containing | 0.656 |