• Version:
  • 11.0 [archived version]
STRINGSTRING
NCBP2L NCBP2L RIMS1 RIMS1 SLC17A5 SLC17A5 CAGE1 CAGE1 DDX53 DDX53 DDX43 DDX43 SAGE1 SAGE1 BOP1 BOP1 MAGEA1 MAGEA1 DHX15 DHX15 OOEP OOEP
"DDX43" - Probable ATP-dependent RNA helicase DDX43 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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Cooccurence
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[Homology]
Score
DDX43Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 (648 aa)    
Predicted Functional Partners:
SAGE1
Sarcoma antigen 1 (904 aa)
     
   
  0.806
MAGEA1
Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family (309 aa)
           
  0.756
DDX53
Probable ATP-dependent RNA helicase DDX53; DEAD-box helicase 53 (631 aa)
   
 
 
0.701
DHX15
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily (795 aa)
     
 
  0.618
RIMS1
Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes; PDZ domain containing (1692 aa)
           
  0.591
OOEP
Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the KHDC1 family (149 aa)
     
   
  0.574
CAGE1
Cancer-associated gene 1 protein; Cancer antigen 1 (839 aa)
           
  0.570
SLC17A5
Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva; Belongs to the major facilitator [...] (495 aa)
           
  0.564
BOP1
Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family (746 aa)
     
 
  0.557
NCBP2L
Nuclear cap binding protein subunit 2 like; Belongs to the RRM NCBP2 family (153 aa)
       
 
  0.553
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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