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  • 11.0 [archived version]
STRINGSTRING
METTL8 METTL8 HEPACAM2 HEPACAM2 C10orf55 C10orf55 PLCXD2 PLCXD2 TMEM56 TMEM56 CCDC74A CCDC74A FAM168B FAM168B CFAP57 CFAP57 SLC25A21 SLC25A21 CCDC144A CCDC144A RWDD3 RWDD3
"TMEM56" - Transmembrane protein 56 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMEM56Transmembrane protein 56; TLC domain containing (263 aa)    
Predicted Functional Partners:
FAM168B
Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) (195 aa)
           
  0.621
RWDD3
RWD domain-containing protein 3; Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional acti [...] (267 aa)
 
       
  0.598
CCDC74A
Coiled-coil domain containing 74A (378 aa)
           
  0.597
METTL8
Methyltransferase-like protein 8; Probable methyltransferase; Belongs to the methyltransferase superfamily. METL family (407 aa)
           
  0.572
CFAP57
Cilia and flagella associated protein 57 (1283 aa)
           
  0.554
C10orf55
Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55 (151 aa)
           
  0.541
CCDC144A
Coiled-coil domain containing 144A (1427 aa)
           
  0.532
PLCXD2
PI-PLC X domain-containing protein 2; Phosphatidylinositol specific phospholipase C X domain containing 2 (305 aa)
     
 
  0.526
HEPACAM2
HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes- anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation; I-set domain containing (485 aa)
           
  0.515
SLC25A21
Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate; Belongs to the mitochondrial carrier (TC 2.A.29) family (299 aa)
     
   
  0.496
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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