| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARX | LMO1 | ENSP00000368332 | ENSP00000338207 | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | 0.481 |
| ARX | TLX1 | ENSP00000368332 | ENSP00000359215 | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.751 |
| LMO1 | ARX | ENSP00000338207 | ENSP00000368332 | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily | 0.481 |
| LMO1 | LMO2 | ENSP00000338207 | ENSP00000257818 | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing | 0.904 |
| LMO1 | LYL1 | ENSP00000338207 | ENSP00000264824 | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | Protein lyl-1; LYL1, basic helix-loop-helix family member | 0.812 |
| LMO1 | TLX1 | ENSP00000338207 | ENSP00000359215 | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.755 |
| LMO2 | LMO1 | ENSP00000257818 | ENSP00000338207 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | 0.904 |
| LMO2 | LYL1 | ENSP00000257818 | ENSP00000264824 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing | Protein lyl-1; LYL1, basic helix-loop-helix family member | 0.894 |
| LMO2 | TLX1 | ENSP00000257818 | ENSP00000359215 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.749 |
| LYL1 | LMO1 | ENSP00000264824 | ENSP00000338207 | Protein lyl-1; LYL1, basic helix-loop-helix family member | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing | 0.812 |
| LYL1 | LMO2 | ENSP00000264824 | ENSP00000257818 | Protein lyl-1; LYL1, basic helix-loop-helix family member | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing | 0.894 |
| LYL1 | TLX1 | ENSP00000264824 | ENSP00000359215 | Protein lyl-1; LYL1, basic helix-loop-helix family member | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.721 |
| PAX2 | SIX2 | ENSP00000359319 | ENSP00000304502 | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD class homeoboxes and pseudogenes | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | 0.796 |
| PAX2 | TLX1 | ENSP00000359319 | ENSP00000359215 | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD class homeoboxes and pseudogenes | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.764 |
| PRDM13 | TLX1 | ENSP00000358217 | ENSP00000359215 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; PR/SET domain family | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.787 |
| SIX2 | PAX2 | ENSP00000304502 | ENSP00000359319 | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD class homeoboxes and pseudogenes | 0.796 |
| SIX2 | TLE1 | ENSP00000304502 | ENSP00000365682 | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG; Belongs to the WD repeat Groucho/TLE family | 0.491 |
| SIX2 | TLX1 | ENSP00000304502 | ENSP00000359215 | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.773 |
| TLE1 | SIX2 | ENSP00000365682 | ENSP00000304502 | Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG; Belongs to the WD repeat Groucho/TLE family | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | 0.491 |
| TLE1 | TLX1 | ENSP00000365682 | ENSP00000359215 | Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG; Belongs to the WD repeat Groucho/TLE family | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’; NKL subclass homeoboxes and pseudogenes | 0.725 |
