• Version:
  • 11.0 [archived version]
STRINGSTRING
SEPT3 SEPT3 ATP6V1C1 ATP6V1C1 FAM84B FAM84B ZNF547 ZNF547 CCNL1 CCNL1 AFTPH AFTPH C10orf76 C10orf76 KCNRG KCNRG CC2D1B CC2D1B GPATCH3 GPATCH3 AMMECR1L AMMECR1L
"C10orf76" - UPF0668 protein C10orf76 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C10orf76UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 (689 aa)    
Predicted Functional Partners:
AFTPH
Aftiphilin; May play a role in membrane trafficking (936 aa)
     
   
  0.719
ZNF547
Zinc finger protein 547; May be involved in transcriptional regulation; Zinc fingers C2H2-type (402 aa)
           
  0.709
SEPT3
Neuronal-specific septin-3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family (358 aa)
           
  0.626
ATP6V1C1
V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (382 aa)
           
  0.626
FAM84B
Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family (310 aa)
           
  0.577
KCNRG
Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (272 aa)
           
  0.573
CCNL1
Cyclin-L1; Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (526 aa)
           
  0.559
GPATCH3
G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] (525 aa)
           
  0.554
CC2D1B
Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing (858 aa)
           
  0.547
AMMECR1L
AMMECR1-like protein; AMMECR1 like (310 aa)
           
  0.530
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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