SFXN2 protein (human) - STRING database

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Score

SFXN2

Sideroflexin-2; Potential iron transporter; Sideroflexins (322 aa)

Predicted Functional Partners:

SPG7

0.876

TOMM7

0.819

TOMM70A

0.804

SVEP1

0.626

SNRNP200

0.626

NDUFAF6

0.550

HSPA14

0.539

EIF1B

0.530

SLC25A1

0.527

SLC25A19

0.514

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF1B	SFXN2	ENSP00000232905	ENSP00000358909	Eukaryotic translation initiation factor 1b; Probably involved in translation	Sideroflexin-2; Potential iron transporter; Sideroflexins	0.530
HSPA14	SFXN2	ENSP00000367623	ENSP00000358909	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	Sideroflexin-2; Potential iron transporter; Sideroflexins	0.539
HSPA14	SNRNP200	ENSP00000367623	ENSP00000317123	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.588
HSPA14	SVEP1	ENSP00000367623	ENSP00000384917	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process; Sushi domain containing	0.610
NDUFAF6	SFXN2	ENSP00000379430	ENSP00000358909	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1	Sideroflexin-2; Potential iron transporter; Sideroflexins	0.550
NDUFAF6	SLC25A19	ENSP00000379430	ENSP00000385312	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1	Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria; Solute carriers	0.690
SFXN2	EIF1B	ENSP00000358909	ENSP00000232905	Sideroflexin-2; Potential iron transporter; Sideroflexins	Eukaryotic translation initiation factor 1b; Probably involved in translation	0.530
SFXN2	HSPA14	ENSP00000358909	ENSP00000367623	Sideroflexin-2; Potential iron transporter; Sideroflexins	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	0.539
SFXN2	NDUFAF6	ENSP00000358909	ENSP00000379430	Sideroflexin-2; Potential iron transporter; Sideroflexins	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1	0.550
SFXN2	SLC25A1	ENSP00000358909	ENSP00000215882	Sideroflexin-2; Potential iron transporter; Sideroflexins	Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway; Solute carriers	0.527
SFXN2	SLC25A19	ENSP00000358909	ENSP00000385312	Sideroflexin-2; Potential iron transporter; Sideroflexins	Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria; Solute carriers	0.514
SFXN2	SNRNP200	ENSP00000358909	ENSP00000317123	Sideroflexin-2; Potential iron transporter; Sideroflexins	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	0.626
SFXN2	SPG7	ENSP00000358909	ENSP00000268704	Sideroflexin-2; Potential iron transporter; Sideroflexins	Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function; In the N-terminal section; belongs to the AAA ATPase family	0.876
SFXN2	SVEP1	ENSP00000358909	ENSP00000384917	Sideroflexin-2; Potential iron transporter; Sideroflexins	Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process; Sushi domain containing	0.626
SFXN2	TOMM7	ENSP00000358909	ENSP00000351214	Sideroflexin-2; Potential iron transporter; Sideroflexins	Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria; Belongs to the Tom7 family	0.819
SFXN2	TOMM70A	ENSP00000358909	ENSP00000284320	Sideroflexin-2; Potential iron transporter; Sideroflexins	Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins	0.804
SLC25A1	SFXN2	ENSP00000215882	ENSP00000358909	Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway; Solute carriers	Sideroflexin-2; Potential iron transporter; Sideroflexins	0.527
SLC25A19	NDUFAF6	ENSP00000385312	ENSP00000379430	Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria; Solute carriers	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1	0.690
SLC25A19	SFXN2	ENSP00000385312	ENSP00000358909	Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria; Solute carriers	Sideroflexin-2; Potential iron transporter; Sideroflexins	0.514
SNRNP200	HSPA14	ENSP00000317123	ENSP00000367623	U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome	Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family	0.588

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