| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMIGO1 | ATXN7L2 | ENSP00000358880 | ENSP00000358886 | Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the immunoglobulin superfamil [...] | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.475 |
| AP4E1 | AP4M1 | ENSP00000261842 | ENSP00000352603 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] | 0.994 |
| AP4E1 | ATXN7L2 | ENSP00000261842 | ENSP00000358886 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.520 |
| AP4M1 | AP4E1 | ENSP00000352603 | ENSP00000261842 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.994 |
| AP4M1 | ATXN7L2 | ENSP00000352603 | ENSP00000358886 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.512 |
| ARV1 | ATXN7L2 | ENSP00000312458 | ENSP00000358886 | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.706 |
| ATXN7L2 | AMIGO1 | ENSP00000358886 | ENSP00000358880 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the immunoglobulin superfamil [...] | 0.475 |
| ATXN7L2 | AP4E1 | ENSP00000358886 | ENSP00000261842 | Ataxin-7-like protein 2; Ataxin 7 like 2 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper [...] | 0.520 |
| ATXN7L2 | AP4M1 | ENSP00000358886 | ENSP00000352603 | Ataxin-7-like protein 2; Ataxin 7 like 2 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] | 0.512 |
| ATXN7L2 | ARV1 | ENSP00000358886 | ENSP00000312458 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes | 0.706 |
| ATXN7L2 | ATXN7L3 | ENSP00000358886 | ENSP00000397259 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] | 0.696 |
| ATXN7L2 | BRSK1 | ENSP00000358886 | ENSP00000310649 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE [...] | 0.476 |
| ATXN7L2 | CSMD3 | ENSP00000358886 | ENSP00000297405 | Ataxin-7-like protein 2; Ataxin 7 like 2 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.558 |
| ATXN7L2 | CYB561D1 | ENSP00000358886 | ENSP00000358884 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Cytochrome b561 family member D1 | 0.552 |
| ATXN7L2 | RNF39 | ENSP00000358886 | ENSP00000244360 | Ataxin-7-like protein 2; Ataxin 7 like 2 | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins | 0.538 |
| ATXN7L2 | RUSC2 | ENSP00000358886 | ENSP00000393922 | Ataxin-7-like protein 2; Ataxin 7 like 2 | Iporin; RUN and SH3 domain containing 2 | 0.650 |
| ATXN7L3 | ATXN7L2 | ENSP00000397259 | ENSP00000358886 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.696 |
| BRSK1 | ATXN7L2 | ENSP00000310649 | ENSP00000358886 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE [...] | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.476 |
| BRSK1 | RUSC2 | ENSP00000310649 | ENSP00000393922 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE [...] | Iporin; RUN and SH3 domain containing 2 | 0.428 |
| CSMD3 | ATXN7L2 | ENSP00000297405 | ENSP00000358886 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Ataxin-7-like protein 2; Ataxin 7 like 2 | 0.558 |
