| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABI1 | EPS8L3 | ENSP00000365312 | ENSP00000358820 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recrui [...] | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.671 |
| AGR2 | EPS8L3 | ENSP00000391490 | ENSP00000358820 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion; Protein disulfide isomerases | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.585 |
| AGR2 | SLC44A4 | ENSP00000391490 | ENSP00000229729 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion; Protein disulfide isomerases | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis; Deafness associated genes | 0.433 |
| EPS8L3 | ABI1 | ENSP00000358820 | ENSP00000365312 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recrui [...] | 0.671 |
| EPS8L3 | AGR2 | ENSP00000358820 | ENSP00000391490 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion; Protein disulfide isomerases | 0.585 |
| EPS8L3 | IGSF23 | ENSP00000358820 | ENSP00000385592 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.633 |
| EPS8L3 | REG4 | ENSP00000358820 | ENSP00000346158 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | 0.654 |
| EPS8L3 | SLC44A4 | ENSP00000358820 | ENSP00000229729 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis; Deafness associated genes | 0.585 |
| EPS8L3 | SLC45A4 | ENSP00000358820 | ENSP00000428137 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family | 0.725 |
| EPS8L3 | SLC6A19 | ENSP00000358820 | ENSP00000305302 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.661 |
| EPS8L3 | STRIP1 | ENSP00000358820 | ENSP00000358810 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; STRIPAK complex | 0.748 |
| EPS8L3 | USH1C | ENSP00000358820 | ENSP00000005226 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Harmonin; Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips; Deafness associated genes | 0.661 |
| EPS8L3 | ZFYVE28 | ENSP00000358820 | ENSP00000290974 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | 0.716 |
| IGSF23 | EPS8L3 | ENSP00000385592 | ENSP00000358820 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.633 |
| IGSF23 | REG4 | ENSP00000385592 | ENSP00000346158 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | 0.716 |
| IGSF23 | SLC6A19 | ENSP00000385592 | ENSP00000305302 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.535 |
| IGSF23 | USH1C | ENSP00000385592 | ENSP00000005226 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | Harmonin; Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips; Deafness associated genes | 0.502 |
| REG4 | EPS8L3 | ENSP00000346158 | ENSP00000358820 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 | 0.654 |
| REG4 | IGSF23 | ENSP00000346158 | ENSP00000385592 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing | 0.716 |
| REG4 | SLC6A19 | ENSP00000346158 | ENSP00000305302 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium; C-type lectin domain containing | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.537 |
