node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALX3 | C1orf87 | ENSP00000358807 | ENSP00000360244 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Uncharacterized protein C1orf87; Chromosome 1 open reading frame 87 | 0.657 |
ALX3 | CDK14 | ENSP00000358807 | ENSP00000369390 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at ’Ser-1490’, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuro [...] | 0.608 |
ALX3 | FERD3L | ENSP00000358807 | ENSP00000275461 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | 0.738 |
ALX3 | MRTO4 | ENSP00000358807 | ENSP00000364320 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes | 0.750 |
ALX3 | PDIA3 | ENSP00000358807 | ENSP00000300289 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Protein disulfide-isomerase A3; Protein disulfide isomerase family A member 3; Belongs to the protein disulfide isomerase family | 0.633 |
ALX3 | PJA1 | ENSP00000358807 | ENSP00000355014 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | E3 ubiquitin-protein ligase Praja-1; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting; Ring finger proteins | 0.650 |
ALX3 | SLC6A17 | ENSP00000358807 | ENSP00000330199 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity); Solute carriers | 0.723 |
ALX3 | TCF12 | ENSP00000358807 | ENSP00000388940 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.657 |
ALX3 | UBL4B | ENSP00000358807 | ENSP00000334044 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Ubiquitin-like protein 4B; Ubiquitin like 4B | 0.745 |
ALX3 | ZSWIM6 | ENSP00000358807 | ENSP00000252744 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | Zinc finger SWIM-type containing 6 | 0.810 |
C1orf87 | ALX3 | ENSP00000360244 | ENSP00000358807 | Uncharacterized protein C1orf87; Chromosome 1 open reading frame 87 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.657 |
CDK14 | ALX3 | ENSP00000369390 | ENSP00000358807 | Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at ’Ser-1490’, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuro [...] | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.608 |
FERD3L | ALX3 | ENSP00000275461 | ENSP00000358807 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.738 |
FERD3L | TCF12 | ENSP00000275461 | ENSP00000388940 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.855 |
MRTO4 | ALX3 | ENSP00000364320 | ENSP00000358807 | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.750 |
PDIA3 | ALX3 | ENSP00000300289 | ENSP00000358807 | Protein disulfide-isomerase A3; Protein disulfide isomerase family A member 3; Belongs to the protein disulfide isomerase family | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.633 |
PJA1 | ALX3 | ENSP00000355014 | ENSP00000358807 | E3 ubiquitin-protein ligase Praja-1; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting; Ring finger proteins | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.650 |
SLC6A17 | ALX3 | ENSP00000330199 | ENSP00000358807 | Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity); Solute carriers | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.723 |
SLC6A17 | UBL4B | ENSP00000330199 | ENSP00000334044 | Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity); Solute carriers | Ubiquitin-like protein 4B; Ubiquitin like 4B | 0.904 |
TCF12 | ALX3 | ENSP00000388940 | ENSP00000358807 | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes | 0.657 |