ME1 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

ME1

Malic enzyme 1 (572 aa)

Predicted Functional Partners:

PC

0.979

MDH2

0.978

PKM

0.978

MDH1

0.975

FH

0.967

PKLR

0.963

PDHA1

0.933

ACOX1

0.928

PDHB

0.925

CS

0.923

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOX1	CS	ENSP00000293217	ENSP00000342056	Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA	Citrate synthase, mitochondrial; Citrate synthase	0.477
ACOX1	ME1	ENSP00000293217	ENSP00000358719	Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA	Malic enzyme 1	0.928
CS	ACOX1	ENSP00000342056	ENSP00000293217	Citrate synthase, mitochondrial; Citrate synthase	Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA	0.477
CS	FH	ENSP00000342056	ENSP00000355518	Citrate synthase, mitochondrial; Citrate synthase	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	0.994
CS	MDH1	ENSP00000342056	ENSP00000438144	Citrate synthase, mitochondrial; Citrate synthase	Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1; Belongs to the LDH/MDH superfamily. MDH type 2 family	0.986
CS	MDH2	ENSP00000342056	ENSP00000327070	Citrate synthase, mitochondrial; Citrate synthase	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2	0.997
CS	ME1	ENSP00000342056	ENSP00000358719	Citrate synthase, mitochondrial; Citrate synthase	Malic enzyme 1	0.923
CS	PC	ENSP00000342056	ENSP00000377532	Citrate synthase, mitochondrial; Citrate synthase	Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.991
CS	PDHA1	ENSP00000342056	ENSP00000369134	Citrate synthase, mitochondrial; Citrate synthase	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle	0.649
CS	PDHB	ENSP00000342056	ENSP00000307241	Citrate synthase, mitochondrial; Citrate synthase	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle	0.641
CS	PKLR	ENSP00000342056	ENSP00000339933	Citrate synthase, mitochondrial; Citrate synthase	Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family	0.733
CS	PKM	ENSP00000342056	ENSP00000320171	Citrate synthase, mitochondrial; Citrate synthase	Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...]	0.772
FH	CS	ENSP00000355518	ENSP00000342056	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Citrate synthase, mitochondrial; Citrate synthase	0.994
FH	MDH1	ENSP00000355518	ENSP00000438144	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1; Belongs to the LDH/MDH superfamily. MDH type 2 family	0.983
FH	MDH2	ENSP00000355518	ENSP00000327070	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2	0.997
FH	ME1	ENSP00000355518	ENSP00000358719	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Malic enzyme 1	0.967
FH	PC	ENSP00000355518	ENSP00000377532	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.886
FH	PDHA1	ENSP00000355518	ENSP00000369134	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle	0.669
FH	PDHB	ENSP00000355518	ENSP00000307241	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle	0.656
FH	PKLR	ENSP00000355518	ENSP00000339933	Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily	Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family	0.558

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