node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf100 | CFAP58 | ENSP00000311218 | ENSP00000358718 | Uncharacterized protein C1orf100; Chromosome 1 open reading frame 100 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | 0.473 |
CBFA2T2 | CFAP58 | ENSP00000262653 | ENSP00000358718 | Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33- dependent manner. May function as a complex with the chimeric protein RUNX1/AML1 [...] | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | 0.626 |
CCDC146 | CCDC40 | ENSP00000285871 | ENSP00000380679 | Coiled-coil domain containing 146 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | 0.753 |
CCDC146 | CFAP58 | ENSP00000285871 | ENSP00000358718 | Coiled-coil domain containing 146 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | 0.444 |
CCDC146 | DNAI2 | ENSP00000285871 | ENSP00000400252 | Coiled-coil domain containing 146 | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family | 0.599 |
CCDC146 | DYNC2LI1 | ENSP00000285871 | ENSP00000474032 | Coiled-coil domain containing 146 | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length; Dyneins, cytoplasmic | 0.626 |
CCDC40 | CCDC146 | ENSP00000380679 | ENSP00000285871 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | Coiled-coil domain containing 146 | 0.753 |
CCDC40 | CFAP58 | ENSP00000380679 | ENSP00000358718 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | 0.632 |
CCDC40 | DNAI2 | ENSP00000380679 | ENSP00000400252 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family | 0.777 |
CCDC40 | DYNC2LI1 | ENSP00000380679 | ENSP00000474032 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length; Dyneins, cytoplasmic | 0.524 |
CFAP58 | C1orf100 | ENSP00000358718 | ENSP00000311218 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Uncharacterized protein C1orf100; Chromosome 1 open reading frame 100 | 0.473 |
CFAP58 | CBFA2T2 | ENSP00000358718 | ENSP00000262653 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33- dependent manner. May function as a complex with the chimeric protein RUNX1/AML1 [...] | 0.626 |
CFAP58 | CCDC146 | ENSP00000358718 | ENSP00000285871 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Coiled-coil domain containing 146 | 0.444 |
CFAP58 | CCDC40 | ENSP00000358718 | ENSP00000380679 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family | 0.632 |
CFAP58 | DNAI2 | ENSP00000358718 | ENSP00000400252 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family | 0.511 |
CFAP58 | DYNC2LI1 | ENSP00000358718 | ENSP00000474032 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length; Dyneins, cytoplasmic | 0.553 |
CFAP58 | HSF5 | ENSP00000358718 | ENSP00000313243 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Heat shock factor protein 5; May act as a transcriptional factor | 0.452 |
CFAP58 | POT1 | ENSP00000358718 | ENSP00000350249 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] | 0.468 |
CFAP58 | ZNF326 | ENSP00000358718 | ENSP00000340796 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family | DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro; Zinc fingers C2H2-type | 0.549 |
DNAI2 | CCDC146 | ENSP00000400252 | ENSP00000285871 | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family | Coiled-coil domain containing 146 | 0.599 |