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  • 11.0 [archived version]
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CCDC146 CCDC146 DNAI2 DNAI2 CCDC40 CCDC40 DYNC2LI1 DYNC2LI1 POT1 POT1 CFAP58 CFAP58 CBFA2T2 CBFA2T2 ZNF326 ZNF326 HSF5 HSF5 C1orf100 C1orf100
"CFAP58" - Cilia and flagella associated protein 58 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CFAP58Cilia and flagella associated protein 58; Belongs to the CFAP58 family (872 aa)    
Predicted Functional Partners:
CCDC40
Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family (1142 aa)
     
   
  0.632
CBFA2T2
Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33- dependent manner. May function as a complex with the chimeric protein RUNX1/AML1 [...] (604 aa)
           
  0.626
DYNC2LI1
Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length; Dyneins, cytoplasmic (352 aa)
     
   
  0.553
ZNF326
DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing- the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro; Zinc fingers C2H2-type (582 aa)
           
  0.549
DNAI2
Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family (605 aa)
     
   
  0.511
C1orf100
Uncharacterized protein C1orf100; Chromosome 1 open reading frame 100 (147 aa)
           
  0.473
POT1
Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] (634 aa)
       
 
  0.468
HSF5
Heat shock factor protein 5; May act as a transcriptional factor (596 aa)
           
  0.452
CCDC146
Coiled-coil domain containing 146 (955 aa)
     
   
0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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