| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC94 | FAM19A3 | ENSP00000262962 | ENSP00000358644 | Coiled-coil domain containing 94 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | 0.671 |
| CCDC94 | LPP | ENSP00000262962 | ENSP00000482472 | Coiled-coil domain containing 94 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | 0.424 |
| CCDC94 | MAST3 | ENSP00000262962 | ENSP00000262811 | Coiled-coil domain containing 94 | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | 0.603 |
| CCDC94 | MSRB3 | ENSP00000262962 | ENSP00000347324 | Coiled-coil domain containing 94 | Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes | 0.536 |
| CCDC94 | RFX2 | ENSP00000262962 | ENSP00000306335 | Coiled-coil domain containing 94 | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters. Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) | 0.439 |
| CCDC94 | WDFY2 | ENSP00000262962 | ENSP00000298125 | Coiled-coil domain containing 94 | WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...] | 0.526 |
| FAM19A3 | CCDC94 | ENSP00000358644 | ENSP00000262962 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Coiled-coil domain containing 94 | 0.671 |
| FAM19A3 | LPP | ENSP00000358644 | ENSP00000482472 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | 0.461 |
| FAM19A3 | MAST3 | ENSP00000358644 | ENSP00000262811 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | 0.653 |
| FAM19A3 | MSRB3 | ENSP00000358644 | ENSP00000347324 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes | 0.626 |
| FAM19A3 | PRR30 | ENSP00000358644 | ENSP00000335017 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Proline-rich protein 30; Proline rich 30 | 0.582 |
| FAM19A3 | RFX2 | ENSP00000358644 | ENSP00000306335 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters. Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) | 0.595 |
| FAM19A3 | SLC16A6 | ENSP00000358644 | ENSP00000319991 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Monocarboxylate transporter 7; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Solute carriers | 0.484 |
| FAM19A3 | TMEM215 | ENSP00000358644 | ENSP00000345468 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | Transmembrane protein 215 | 0.527 |
| FAM19A3 | TRNP1 | ENSP00000358644 | ENSP00000429216 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity) | 0.491 |
| FAM19A3 | WDFY2 | ENSP00000358644 | ENSP00000298125 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...] | 0.623 |
| LPP | CCDC94 | ENSP00000482472 | ENSP00000262962 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | Coiled-coil domain containing 94 | 0.424 |
| LPP | FAM19A3 | ENSP00000482472 | ENSP00000358644 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family | 0.461 |
| LPP | MAST3 | ENSP00000482472 | ENSP00000262811 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family | 0.459 |
| LPP | MSRB3 | ENSP00000482472 | ENSP00000347324 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus; Zyxin family | Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes | 0.464 |
