node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX5AP | FUNDC2 | ENSP00000479870 | ENSP00000358510 | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes; Belongs to the MAPEG family | FUN14 domain containing 2; Belongs to the FUN14 family | 0.540 |
FBXO39 | FUNDC2 | ENSP00000321386 | ENSP00000358510 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | FUN14 domain containing 2; Belongs to the FUN14 family | 0.654 |
FUNDC1 | FUNDC2 | ENSP00000367284 | ENSP00000358510 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | FUN14 domain containing 2; Belongs to the FUN14 family | 0.527 |
FUNDC1 | MARCH5 | ENSP00000367284 | ENSP00000351813 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | 0.775 |
FUNDC1 | MFF | ENSP00000367284 | ENSP00000302037 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles | 0.568 |
FUNDC1 | PGAM5 | ENSP00000367284 | ENSP00000438465 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.970 |
FUNDC2 | ALOX5AP | ENSP00000358510 | ENSP00000479870 | FUN14 domain containing 2; Belongs to the FUN14 family | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes; Belongs to the MAPEG family | 0.540 |
FUNDC2 | FBXO39 | ENSP00000358510 | ENSP00000321386 | FUN14 domain containing 2; Belongs to the FUN14 family | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.654 |
FUNDC2 | FUNDC1 | ENSP00000358510 | ENSP00000367284 | FUN14 domain containing 2; Belongs to the FUN14 family | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.527 |
FUNDC2 | MARCH5 | ENSP00000358510 | ENSP00000351813 | FUN14 domain containing 2; Belongs to the FUN14 family | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | 0.686 |
FUNDC2 | MFF | ENSP00000358510 | ENSP00000302037 | FUN14 domain containing 2; Belongs to the FUN14 family | Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles | 0.633 |
FUNDC2 | NEDD8 | ENSP00000358510 | ENSP00000250495 | FUN14 domain containing 2; Belongs to the FUN14 family | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins | 0.726 |
FUNDC2 | PGAM5 | ENSP00000358510 | ENSP00000438465 | FUN14 domain containing 2; Belongs to the FUN14 family | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.641 |
FUNDC2 | SERGEF | ENSP00000358510 | ENSP00000265965 | FUN14 domain containing 2; Belongs to the FUN14 family | Secretion-regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process | 0.591 |
FUNDC2 | SREBF1 | ENSP00000358510 | ENSP00000348069 | FUN14 domain containing 2; Belongs to the FUN14 family | Sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’); Basic helix-loop-helix proteins | 0.633 |
FUNDC2 | SYNDIG1 | ENSP00000358510 | ENSP00000366058 | FUN14 domain containing 2; Belongs to the FUN14 family | Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin family | 0.588 |
MARCH5 | FUNDC1 | ENSP00000351813 | ENSP00000367284 | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.775 |
MARCH5 | FUNDC2 | ENSP00000351813 | ENSP00000358510 | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | FUN14 domain containing 2; Belongs to the FUN14 family | 0.686 |
MARCH5 | MFF | ENSP00000351813 | ENSP00000302037 | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles | 0.707 |
MARCH5 | PGAM5 | ENSP00000351813 | ENSP00000438465 | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1; Membrane associated ring-CH-type fingers | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.755 |