IGSF3 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IGSF3

Immunoglobulin superfamily member 3; Immunoglobulin like domain containing (1214 aa)

Predicted Functional Partners:

CROCC

0.673

RABGEF1

0.660

CD9

0.657

TNFRSF14

0.644

CLIC2

0.634

CDR2

0.619

CSF2RB

0.592

ITGAE

0.589

CD81

0.581

IGLL1

0.577

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD81	CD9	ENSP00000263645	ENSP00000371958	CD81 antigen; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV; CD molecules	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	0.430
CD81	IGSF3	ENSP00000263645	ENSP00000358495	CD81 antigen; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV; CD molecules	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.581
CD9	CD81	ENSP00000371958	ENSP00000263645	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	CD81 antigen; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV; CD molecules	0.430
CD9	IGSF3	ENSP00000371958	ENSP00000358495	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.657
CDR2	IGSF3	ENSP00000268383	ENSP00000358495	Cerebellar degeneration related protein 2	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.619
CLIC2	IGSF3	ENSP00000358460	ENSP00000358495	Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.634
CROCC	CSF2RB	ENSP00000364691	ENSP00000384053	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	0.587
CROCC	IGLL1	ENSP00000364691	ENSP00000329312	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	0.557
CROCC	IGSF3	ENSP00000364691	ENSP00000358495	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.673
CROCC	RABGEF1	ENSP00000364691	ENSP00000370208	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	RAB guanine nucleotide exchange factor 1; VPS9 domain containing	0.653
CROCC	TNFRSF14	ENSP00000364691	ENSP00000347948	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	Tumor necrosis factor receptor superfamily member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells; CD molecules	0.634
CSF2RB	CROCC	ENSP00000384053	ENSP00000364691	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	0.587
CSF2RB	IGLL1	ENSP00000384053	ENSP00000329312	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	0.459
CSF2RB	IGSF3	ENSP00000384053	ENSP00000358495	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.592
CSF2RB	RABGEF1	ENSP00000384053	ENSP00000370208	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	RAB guanine nucleotide exchange factor 1; VPS9 domain containing	0.580
CSF2RB	TNFRSF14	ENSP00000384053	ENSP00000347948	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	Tumor necrosis factor receptor superfamily member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells; CD molecules	0.657
IGLL1	CROCC	ENSP00000329312	ENSP00000364691	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis	0.557
IGLL1	CSF2RB	ENSP00000329312	ENSP00000384053	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules	0.459
IGLL1	IGSF3	ENSP00000329312	ENSP00000358495	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	Immunoglobulin superfamily member 3; Immunoglobulin like domain containing	0.577
IGLL1	RABGEF1	ENSP00000329312	ENSP00000370208	Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing	RAB guanine nucleotide exchange factor 1; VPS9 domain containing	0.548

page 1 of 3

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About