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  • 11.0 [archived version]
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ZDHHC1 ZDHHC1 SPRYD7 SPRYD7 VPS11 VPS11 VPS18 VPS18 INTS10 INTS10 VPS16 VPS16 KLHL32 KLHL32 GALNT10 GALNT10 NFE2L3 NFE2L3 GPR63 GPR63 NDUFA4 NDUFA4
"KLHL32" - Kelch-like protein 32 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
KLHL32Kelch-like protein 32; Kelch like family member 32; BTB domain containing (620 aa)    
Predicted Functional Partners:
VPS11
Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] (941 aa)
       
      0.764
GPR63
Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans (419 aa)
           
  0.630
GALNT10
Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates; Polypeptide N-acetylgalactosaminyltransferases (603 aa)
     
   
  0.586
INTS10
Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (710 aa)
           
  0.581
NDUFA4
Cytochrome c oxidase subunit NDUFA4; Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (81 aa)
     
   
  0.557
SPRYD7
SPRY domain containing 7 (196 aa)
           
  0.548
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] (839 aa)
       
      0.543
VPS18
Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] (973 aa)
       
      0.543
NFE2L3
Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins (694 aa)
           
  0.526
ZDHHC1
Probable palmitoyltransferase ZDHHC1; Zinc finger DHHC-type containing 1; Belongs to the DHHC palmitoyltransferase family (485 aa)
     
   
  0.495
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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