GJA8 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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GJA8

Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (433 aa)

Predicted Functional Partners:

CRYA1

0.835

MIP

0.832

HSPB4

0.832

CRYBB2

0.814

CRYBB1

0.813

GJE1

0.802

TJP1

0.795

CRYBA1

0.775

BFSP2

0.762

CRYGD

0.760

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFSP2	CRYA1	ENSP00000304987	ENSP00000482816	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	CRYBA1	ENSP00000304987	ENSP00000225387	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	0.784
BFSP2	CRYBB1	ENSP00000304987	ENSP00000215939	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.798
BFSP2	CRYBB2	ENSP00000304987	ENSP00000381273	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.812
BFSP2	CRYGD	ENSP00000304987	ENSP00000264376	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens	0.749
BFSP2	GJA8	ENSP00000304987	ENSP00000358238	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.762
BFSP2	HSPB4	ENSP00000304987	ENSP00000291554	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	MIP	ENSP00000304987	ENSP00000257979	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.814
CRYA1	BFSP2	ENSP00000482816	ENSP00000304987	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.819
CRYA1	CRYBA1	ENSP00000482816	ENSP00000225387	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	0.905
CRYA1	CRYBB1	ENSP00000482816	ENSP00000215939	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.940
CRYA1	CRYBB2	ENSP00000482816	ENSP00000381273	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.934
CRYA1	CRYGD	ENSP00000482816	ENSP00000264376	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens	0.814
CRYA1	GJA8	ENSP00000482816	ENSP00000358238	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.835
CRYA1	MIP	ENSP00000482816	ENSP00000257979	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.716
CRYBA1	BFSP2	ENSP00000225387	ENSP00000304987	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.784
CRYBA1	CRYA1	ENSP00000225387	ENSP00000482816	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.905
CRYBA1	CRYBB1	ENSP00000225387	ENSP00000215939	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.721
CRYBA1	CRYBB2	ENSP00000225387	ENSP00000381273	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.413
CRYBA1	GJA8	ENSP00000225387	ENSP00000358238	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.775

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