node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP6 | ANKRD35 | ENSP00000463574 | ENSP00000347802 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | 0.473 |
ACP6 | BCL9 | ENSP00000463574 | ENSP00000234739 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | 0.569 |
ACP6 | CHD1L | ENSP00000463574 | ENSP00000358262 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding; Belongs to the SNF2/RAD54 helicase family | 0.700 |
ACP6 | FMO5 | ENSP00000463574 | ENSP00000254090 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.642 |
ACP6 | GPR89B | ENSP00000463574 | ENSP00000358233 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Golgi pH regulator A; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance; Belongs to the Golgi pH regulator (TC 1.A.38) family | 0.731 |
ACP6 | NBPF11 | ENSP00000463574 | ENSP00000477509 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family | 0.669 |
ACP6 | NUDT17 | ENSP00000463574 | ENSP00000334437 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.510 |
ACP6 | PRKAB2 | ENSP00000463574 | ENSP00000254101 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | 5’-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.676 |
ANKRD35 | ACP6 | ENSP00000347802 | ENSP00000463574 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | 0.473 |
ANKRD35 | FMO5 | ENSP00000347802 | ENSP00000254090 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.419 |
ANKRD35 | GPR89B | ENSP00000347802 | ENSP00000358233 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | Golgi pH regulator A; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance; Belongs to the Golgi pH regulator (TC 1.A.38) family | 0.519 |
ANKRD35 | NBPF11 | ENSP00000347802 | ENSP00000477509 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family | 0.560 |
ANKRD35 | NUDT17 | ENSP00000347802 | ENSP00000334437 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.591 |
ANKRD35 | PRKAB2 | ENSP00000347802 | ENSP00000254101 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing | 5’-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.410 |
BCL9 | ACP6 | ENSP00000234739 | ENSP00000463574 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | 0.569 |
BCL9 | CHD1L | ENSP00000234739 | ENSP00000358262 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding; Belongs to the SNF2/RAD54 helicase family | 0.572 |
BCL9 | FMO5 | ENSP00000234739 | ENSP00000254090 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme | 0.473 |
BCL9 | GPR89B | ENSP00000234739 | ENSP00000358233 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | Golgi pH regulator A; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance; Belongs to the Golgi pH regulator (TC 1.A.38) family | 0.557 |
BCL9 | NBPF11 | ENSP00000234739 | ENSP00000477509 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family | 0.528 |
BCL9 | PRKAB2 | ENSP00000234739 | ENSP00000254101 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin’s transcriptional activity (By similarity); Belongs to the BCL9 family | 5’-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.649 |