| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CGI-74 | LUC7L2 | ENSP00000347005 | ENSP00000440222 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.540 |
| CGI-74 | SCN8A | ENSP00000347005 | ENSP00000346534 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | 0.449 |
| CGI-74 | SCNM1 | ENSP00000347005 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.940 |
| DMXL1 | PRR16 | ENSP00000439479 | ENSP00000385118 | DmX-like protein 1; WD repeat domain containing | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | 0.638 |
| DMXL1 | SCNM1 | ENSP00000439479 | ENSP00000357901 | DmX-like protein 1; WD repeat domain containing | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.634 |
| LUC7L2 | CGI-74 | ENSP00000440222 | ENSP00000347005 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.540 |
| LUC7L2 | SCN8A | ENSP00000440222 | ENSP00000346534 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | 0.449 |
| LUC7L2 | SCNM1 | ENSP00000440222 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.940 |
| NID1 | RNF212 | ENSP00000264187 | ENSP00000389709 | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...] | 0.514 |
| NID1 | SCNM1 | ENSP00000264187 | ENSP00000357901 | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.626 |
| PRR16 | DMXL1 | ENSP00000385118 | ENSP00000439479 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | DmX-like protein 1; WD repeat domain containing | 0.638 |
| PRR16 | SCNM1 | ENSP00000385118 | ENSP00000357901 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.643 |
| RNF212 | NID1 | ENSP00000389709 | ENSP00000264187 | Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...] | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | 0.514 |
| RNF212 | SCNM1 | ENSP00000389709 | ENSP00000357901 | Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis- required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with [...] | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.652 |
| SCN3A | SCN8A | ENSP00000283254 | ENSP00000346534 | Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient; Sodium voltage-gated channel alpha subunits | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | 0.416 |
| SCN3A | SCNM1 | ENSP00000283254 | ENSP00000357901 | Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient; Sodium voltage-gated channel alpha subunits | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.645 |
| SCN7A | SCNM1 | ENSP00000386796 | ENSP00000357901 | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.717 |
| SCN8A | CGI-74 | ENSP00000346534 | ENSP00000347005 | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.449 |
| SCN8A | LUC7L2 | ENSP00000346534 | ENSP00000440222 | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.449 |
| SCN8A | SCN3A | ENSP00000346534 | ENSP00000283254 | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily | Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient; Sodium voltage-gated channel alpha subunits | 0.416 |
