| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP1S3 | IKZF5 | ENSP00000379891 | ENSP00000357881 | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.587 |
| AP1S3 | KIAA0020 | ENSP00000379891 | ENSP00000380982 | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity) | 0.655 |
| IKZF2 | IKZF3 | ENSP00000412869 | ENSP00000344544 | Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin; Zinc fingers C2H2-type | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | 0.410 |
| IKZF2 | IKZF5 | ENSP00000412869 | ENSP00000357881 | Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin; Zinc fingers C2H2-type | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.657 |
| IKZF3 | IKZF2 | ENSP00000344544 | ENSP00000412869 | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin; Zinc fingers C2H2-type | 0.410 |
| IKZF3 | IKZF4 | ENSP00000344544 | ENSP00000262032 | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | 0.906 |
| IKZF3 | IKZF5 | ENSP00000344544 | ENSP00000357881 | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.631 |
| IKZF4 | IKZF3 | ENSP00000262032 | ENSP00000344544 | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | 0.906 |
| IKZF4 | IKZF5 | ENSP00000262032 | ENSP00000357881 | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.798 |
| IKZF5 | AP1S3 | ENSP00000357881 | ENSP00000379891 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking | 0.587 |
| IKZF5 | IKZF2 | ENSP00000357881 | ENSP00000412869 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin; Zinc fingers C2H2-type | 0.657 |
| IKZF5 | IKZF3 | ENSP00000357881 | ENSP00000344544 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family | 0.631 |
| IKZF5 | IKZF4 | ENSP00000357881 | ENSP00000262032 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | 0.798 |
| IKZF5 | KAT2A | ENSP00000357881 | ENSP00000225916 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Histone acetyltransferase KAT2A; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may [...] | 0.573 |
| IKZF5 | KAT2B | ENSP00000357881 | ENSP00000263754 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadia [...] | 0.573 |
| IKZF5 | KIAA0020 | ENSP00000357881 | ENSP00000380982 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity) | 0.530 |
| IKZF5 | SH3BP5L | ENSP00000357881 | ENSP00000355428 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | SH3 binding domain protein 5 like | 0.548 |
| IKZF5 | TADA2A | ENSP00000357881 | ENSP00000481091 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.566 |
| IKZF5 | TALDO1 | ENSP00000357881 | ENSP00000321259 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway | 0.612 |
| KAT2A | IKZF5 | ENSP00000225916 | ENSP00000357881 | Histone acetyltransferase KAT2A; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may [...] | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor; Zinc fingers C2H2-type | 0.573 |
