• Version:
  • 11.0 [archived version]
STRINGSTRING
LCE2B LCE2B LCE3E LCE3E SPRR3 SPRR3 CRNN CRNN SPRR1B SPRR1B SPRR1A SPRR1A FAM25A FAM25A CRCT1 CRCT1 UBAP2L UBAP2L S100A7A S100A7A C1orf43 C1orf43
"CRCT1" - Cysteine rich C-terminal 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRCT1Cysteine rich C-terminal 1 (99 aa)    
Predicted Functional Partners:
SPRR1B
Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family (89 aa)
     
   
  0.723
SPRR3
Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins (169 aa)
     
   
  0.702
C1orf43
Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 (253 aa)
           
  0.700
S100A7A
Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing (101 aa)
     
   
  0.694
LCE2B
Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum (110 aa)
     
 
  0.682
FAM25A
Family with sequence similarity 25 member A; Belongs to the FAM25 family (89 aa)
     
   
  0.680
LCE3E
Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum (92 aa)
     
   
  0.677
UBAP2L
Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (1087 aa)
           
  0.668
SPRR1A
Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Small proline rich proteins (89 aa)
     
   
  0.661
CRNN
Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family (495 aa)
     
   
  0.660
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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